Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infection
Coronavirus disease 2019 (COVID-19) primarily affects the respiratory tract, but also many other organs and tissues, leading to different pathological pictures, such as those of the musculoskeletal tissues. The present study should be considered as a speculation on the relationship between COVID-19...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.930789/full |
| _version_ | 1818532122886930432 |
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| author | Francesca Veronesi Deyanira Contartese Lucia Martini Andrea Visani Milena Fini |
| author_facet | Francesca Veronesi Deyanira Contartese Lucia Martini Andrea Visani Milena Fini |
| author_sort | Francesca Veronesi |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) primarily affects the respiratory tract, but also many other organs and tissues, leading to different pathological pictures, such as those of the musculoskeletal tissues. The present study should be considered as a speculation on the relationship between COVID-19 infection and some frequent musculoskeletal pathologies, in particular sarcopenia, bone loss/osteoporosis (OP) and fracture risk and osteoarthritis (OA), to hypothesize how the virus acts on these pathologies and consequently on the tissue regeneration/healing potential. The study focuses in particular on the modalities of interaction of COVID-19 with Angiotensin-Converting Enzyme 2 (ACE2) and on the “cytokine storm.” Knowing the effects of COVID-19 on musculoskeletal tissues could be important also to understand if tissue regenerative/reparative capacity is compromised, especially in elderly and frail patients. We speculate that ACE2 and serine proteases together with an intense inflammation, immobilization and malnutrition could be the responsible for muscle weakness, altered bone remodeling, increase in bone fracture risk and inflammatory joint pathologies. Future preclinical and clinical studies may focus on the regenerative/reparative properties of the musculoskeletal tissues after COVID-19 infection, toward a personalized treatment usually based on scaffolds, cells, and growth factors. |
| first_indexed | 2024-12-11T17:41:24Z |
| format | Article |
| id | doaj.art-d93922c386a940feb3b534cd8410ad9c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T17:41:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-d93922c386a940feb3b534cd8410ad9c2022-12-22T00:56:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-07-01910.3389/fmed.2022.930789930789Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infectionFrancesca VeronesiDeyanira ContarteseLucia MartiniAndrea VisaniMilena FiniCoronavirus disease 2019 (COVID-19) primarily affects the respiratory tract, but also many other organs and tissues, leading to different pathological pictures, such as those of the musculoskeletal tissues. The present study should be considered as a speculation on the relationship between COVID-19 infection and some frequent musculoskeletal pathologies, in particular sarcopenia, bone loss/osteoporosis (OP) and fracture risk and osteoarthritis (OA), to hypothesize how the virus acts on these pathologies and consequently on the tissue regeneration/healing potential. The study focuses in particular on the modalities of interaction of COVID-19 with Angiotensin-Converting Enzyme 2 (ACE2) and on the “cytokine storm.” Knowing the effects of COVID-19 on musculoskeletal tissues could be important also to understand if tissue regenerative/reparative capacity is compromised, especially in elderly and frail patients. We speculate that ACE2 and serine proteases together with an intense inflammation, immobilization and malnutrition could be the responsible for muscle weakness, altered bone remodeling, increase in bone fracture risk and inflammatory joint pathologies. Future preclinical and clinical studies may focus on the regenerative/reparative properties of the musculoskeletal tissues after COVID-19 infection, toward a personalized treatment usually based on scaffolds, cells, and growth factors.https://www.frontiersin.org/articles/10.3389/fmed.2022.930789/fullCOVID-19ACE2inflammationbonemusclejoint |
| spellingShingle | Francesca Veronesi Deyanira Contartese Lucia Martini Andrea Visani Milena Fini Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infection Frontiers in Medicine COVID-19 ACE2 inflammation bone muscle joint |
| title | Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infection |
| title_full | Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infection |
| title_fullStr | Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infection |
| title_full_unstemmed | Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infection |
| title_short | Speculation on the pathophysiology of musculoskeletal injury with COVID-19 infection |
| title_sort | speculation on the pathophysiology of musculoskeletal injury with covid 19 infection |
| topic | COVID-19 ACE2 inflammation bone muscle joint |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.930789/full |
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