Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury
Individuals with a history of mild traumatic brain injury (mTBI) are at an increased risk for neurodegenerative disease, suggesting that intrinsic neuroprotective mechanisms, such as the endogenous antioxidant reservoir, may be depleted long-term after mTBI. Here, we retrospectively analyzed symptom...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Advances in Redox Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667137924000043 |
| _version_ | 1797260306756403200 |
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| author | Lilia A. Koza Allison N. Grossberg McKensey Bishop Chad Prusmack Daniel A. Linseman |
| author_facet | Lilia A. Koza Allison N. Grossberg McKensey Bishop Chad Prusmack Daniel A. Linseman |
| author_sort | Lilia A. Koza |
| collection | DOAJ |
| description | Individuals with a history of mild traumatic brain injury (mTBI) are at an increased risk for neurodegenerative disease, suggesting that intrinsic neuroprotective mechanisms, such as the endogenous antioxidant reservoir, may be depleted long-term after mTBI. Here, we retrospectively analyzed symptoms and blood antioxidants in patients with a history of mTBI who presented to Resilience Code, a sports medicine clinic in Colorado. Significant decreases in alpha-tocopherol, selenium, linoleic acid, taurine, docosahexaenoic acid, and total omega-3 were measured in the total mTBI population versus controls. Male mTBI patients showed depletion of a larger array of antioxidants than females. Patients with a history of mTBI also reported significantly worsened emotional, energy, head, and cognitive symptoms, with males displaying more extensive symptomology. Multiple or chronic mTBI patients had worsened symptoms than single or acute/subchronic mTBI patients, respectively. Finally, male mTBI patients with the largest reductions in polyunsaturated fatty acids (PUFAs) displayed worse symptomology than male mTBI patients with less depletion of this antioxidant reservoir. These results demonstrate that antioxidant depletion persists in patients with a history of mTBI and these deficits are sex-specific and associated with worsened symptomology. Furthermore, supplementation with specific antioxidants, like PUFAs, may diminish symptom severity in patients suffering from chronic effects of mTBI. |
| first_indexed | 2024-03-07T18:35:40Z |
| format | Article |
| id | doaj.art-d93b5e1f7f404ad9b56a7b0cc1bec686 |
| institution | Directory Open Access Journal |
| issn | 2667-1379 |
| language | English |
| last_indexed | 2024-04-24T23:23:14Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Redox Research |
| spelling | doaj.art-d93b5e1f7f404ad9b56a7b0cc1bec6862024-03-16T05:09:55ZengElsevierAdvances in Redox Research2667-13792024-04-0110100097Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injuryLilia A. Koza0Allison N. Grossberg1McKensey Bishop2Chad Prusmack3Daniel A. Linseman4Department of Biological Sciences and Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208, United StatesDepartment of Biological Sciences and Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208, United StatesDepartment of Biological Sciences and Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208, United StatesResilience Code, Englewood, CO 80112, United StatesDepartment of Biological Sciences and Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208, United States; Corresponding author at: University of Denver, Engineering & Computer Science Building, Room 553, 2155 E. Wesley Ave, Denver, CO 80208, United States.Individuals with a history of mild traumatic brain injury (mTBI) are at an increased risk for neurodegenerative disease, suggesting that intrinsic neuroprotective mechanisms, such as the endogenous antioxidant reservoir, may be depleted long-term after mTBI. Here, we retrospectively analyzed symptoms and blood antioxidants in patients with a history of mTBI who presented to Resilience Code, a sports medicine clinic in Colorado. Significant decreases in alpha-tocopherol, selenium, linoleic acid, taurine, docosahexaenoic acid, and total omega-3 were measured in the total mTBI population versus controls. Male mTBI patients showed depletion of a larger array of antioxidants than females. Patients with a history of mTBI also reported significantly worsened emotional, energy, head, and cognitive symptoms, with males displaying more extensive symptomology. Multiple or chronic mTBI patients had worsened symptoms than single or acute/subchronic mTBI patients, respectively. Finally, male mTBI patients with the largest reductions in polyunsaturated fatty acids (PUFAs) displayed worse symptomology than male mTBI patients with less depletion of this antioxidant reservoir. These results demonstrate that antioxidant depletion persists in patients with a history of mTBI and these deficits are sex-specific and associated with worsened symptomology. Furthermore, supplementation with specific antioxidants, like PUFAs, may diminish symptom severity in patients suffering from chronic effects of mTBI.http://www.sciencedirect.com/science/article/pii/S2667137924000043Traumatic brain injuryAntioxidantsBiomarkersSymptomologyPolyunsaturated fatty acids |
| spellingShingle | Lilia A. Koza Allison N. Grossberg McKensey Bishop Chad Prusmack Daniel A. Linseman Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury Advances in Redox Research Traumatic brain injury Antioxidants Biomarkers Symptomology Polyunsaturated fatty acids |
| title | Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury |
| title_full | Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury |
| title_fullStr | Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury |
| title_full_unstemmed | Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury |
| title_short | Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury |
| title_sort | sex specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury |
| topic | Traumatic brain injury Antioxidants Biomarkers Symptomology Polyunsaturated fatty acids |
| url | http://www.sciencedirect.com/science/article/pii/S2667137924000043 |
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