Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice

Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice

Ras/Raf/MEK/ERK (Ras-ERK) signaling has been demonstrated to play a role in the effects of drugs of abuse such as cocaine and alcohol, but has not been extensively examined in nicotine-related reward behaviors. We examined the role of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2), an upstream...

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Bibliographic Details
Main Authors: Ilaria Morella, Veronika Pohořalá, Claudia Calpe-López, Riccardo Brambilla, Rainer Spanagel, Rick E. Bernardi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
RasGRF2
nicotine
self-administration (SA)
pERK
extracellar signal-regulated kinase
pERK1/2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.986566/full

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