Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest
Various pathogenic factors can lead to oogenesis failure and seriously affect both female reproductive health and fertility. Genetic factors play an important role in folliculogenesis and oocyte maturation but still need to be clarified. Oocyte maturation is a well-organized complex process, regulat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/11/1920 |
| _version_ | 1797468183430430720 |
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| author | Olga Aleksandrovna Solovova Vyacheslav Borisovich Chernykh |
| author_facet | Olga Aleksandrovna Solovova Vyacheslav Borisovich Chernykh |
| author_sort | Olga Aleksandrovna Solovova |
| collection | DOAJ |
| description | Various pathogenic factors can lead to oogenesis failure and seriously affect both female reproductive health and fertility. Genetic factors play an important role in folliculogenesis and oocyte maturation but still need to be clarified. Oocyte maturation is a well-organized complex process, regulated by a large number of genes. Pathogenic variants in these genes as well as aneuploidy, defects in mitochondrial genome, and other genetic and epigenetic factors can result in unexplained infertility, early pregnancy loss, and recurrent failures of IVF/ICSI programs due to poor ovarian response to stimulation, oocyte maturation arrest, poor gamete quality, fertilization failure, or early embryonic developmental arrest. In this paper, we review the main genes, as well as provide a description of the defects in the mitochondrial genome, associated with female infertility. |
| first_indexed | 2024-03-09T19:03:56Z |
| format | Article |
| id | doaj.art-d93e5863e5e64985af08a6c6545d3661 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T19:03:56Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-d93e5863e5e64985af08a6c6545d36612023-11-24T04:46:55ZengMDPI AGGenes2073-44252022-10-011311192010.3390/genes13111920Genetics of Oocyte Maturation Defects and Early Embryo Development ArrestOlga Aleksandrovna Solovova0Vyacheslav Borisovich Chernykh1Moscow Regional Research and Clinical Institute (MONIKI), Schepkina st. 61/2, 129110 Moscow, RussiaResearch Centre for Medical Genetics, Moskvorechie St. 1, 115522 Moscow, RussiaVarious pathogenic factors can lead to oogenesis failure and seriously affect both female reproductive health and fertility. Genetic factors play an important role in folliculogenesis and oocyte maturation but still need to be clarified. Oocyte maturation is a well-organized complex process, regulated by a large number of genes. Pathogenic variants in these genes as well as aneuploidy, defects in mitochondrial genome, and other genetic and epigenetic factors can result in unexplained infertility, early pregnancy loss, and recurrent failures of IVF/ICSI programs due to poor ovarian response to stimulation, oocyte maturation arrest, poor gamete quality, fertilization failure, or early embryonic developmental arrest. In this paper, we review the main genes, as well as provide a description of the defects in the mitochondrial genome, associated with female infertility.https://www.mdpi.com/2073-4425/13/11/1920embryofemale infertilityfertilizationgeneshuman reproductionoocyte |
| spellingShingle | Olga Aleksandrovna Solovova Vyacheslav Borisovich Chernykh Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest Genes embryo female infertility fertilization genes human reproduction oocyte |
| title | Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest |
| title_full | Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest |
| title_fullStr | Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest |
| title_full_unstemmed | Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest |
| title_short | Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest |
| title_sort | genetics of oocyte maturation defects and early embryo development arrest |
| topic | embryo female infertility fertilization genes human reproduction oocyte |
| url | https://www.mdpi.com/2073-4425/13/11/1920 |
| work_keys_str_mv | AT olgaaleksandrovnasolovova geneticsofoocytematurationdefectsandearlyembryodevelopmentarrest AT vyacheslavborisovichchernykh geneticsofoocytematurationdefectsandearlyembryodevelopmentarrest |