New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii
Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configurat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/10/2467 |
| _version_ | 1818386719082283008 |
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| author | Lin Ni Ying-da Zang Jing-zhi Yang Chuang-jun Li Jie Ma Dong-ming Zhang |
| author_facet | Lin Ni Ying-da Zang Jing-zhi Yang Chuang-jun Li Jie Ma Dong-ming Zhang |
| author_sort | Lin Ni |
| collection | DOAJ |
| description | Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro. |
| first_indexed | 2024-12-14T03:58:31Z |
| format | Article |
| id | doaj.art-d93ebb15880f4f2aaf04849d825cc08a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T03:58:31Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d93ebb15880f4f2aaf04849d825cc08a2022-12-21T23:18:02ZengMDPI AGMolecules1420-30492018-09-012310246710.3390/molecules23102467molecules23102467New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordiiLin Ni0Ying-da Zang1Jing-zhi Yang2Chuang-jun Li3Jie Ma4Dong-ming Zhang5State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaThree 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro.http://www.mdpi.com/1420-3049/23/10/2467Tripterygium wilfordiitripordolideX-rayNO |
| spellingShingle | Lin Ni Ying-da Zang Jing-zhi Yang Chuang-jun Li Jie Ma Dong-ming Zhang New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii Molecules Tripterygium wilfordii tripordolide X-ray NO |
| title | New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii |
| title_full | New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii |
| title_fullStr | New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii |
| title_full_unstemmed | New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii |
| title_short | New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii |
| title_sort | new 18 4 3 abeo abietanoids from tripterygium wilfordii |
| topic | Tripterygium wilfordii tripordolide X-ray NO |
| url | http://www.mdpi.com/1420-3049/23/10/2467 |
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