Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures
There is increasing human and animal evidence that brain oscillations play a critical role in the development of spatial cognition. In rat pups, disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition. Early-life seizu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996123000359 |
| _version_ | 1811165436561063936 |
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| author | Francisco Velasquez Conor Dickson Michelle L. Kloc Carmel A. Schneur Jeremy M. Barry Gregory L. Holmes |
| author_facet | Francisco Velasquez Conor Dickson Michelle L. Kloc Carmel A. Schneur Jeremy M. Barry Gregory L. Holmes |
| author_sort | Francisco Velasquez |
| collection | DOAJ |
| description | There is increasing human and animal evidence that brain oscillations play a critical role in the development of spatial cognition. In rat pups, disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition. Early-life seizures are associated with long-term deficits in spatial cognition and aberrant hippocampal oscillatory activity. Here we asked whether modulation of hippocampal rhythms following early-life seizures can reverse or improve hippocampal connectivity and spatial cognition. We used optogenetic stimulation of the medial septum to induce physiological 7 Hz theta oscillations in the hippocampus during the critical period of spatial cognition following early-life seizures.Optogenetic stimulation of the medial septum in control and rats subjected to early-life seizures resulted in precisely regulated frequency-matched hippocampal oscillations. Rat pups receiving active blue light stimulation performed better than the rats receiving inert yellow light in a test of spatial cognition. The improvement in spatial cognition in these rats was associated with a faster theta frequency and higher theta power, coherence and phase locking value in the hippocampus than rats with early-life seizures receiving inert yellow light. These findings indicate that following early life seizures, modification of hippocampal rhythms may be a potential novel therapeutic modality. |
| first_indexed | 2024-04-10T15:37:07Z |
| format | Article |
| id | doaj.art-d93fc8b0b7444bcd84d0262066b6377b |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-04-10T15:37:07Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-d93fc8b0b7444bcd84d0262066b6377b2023-02-13T04:06:55ZengElsevierNeurobiology of Disease1095-953X2023-03-01178106021Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizuresFrancisco Velasquez0Conor Dickson1Michelle L. Kloc2Carmel A. Schneur3Jeremy M. Barry4Gregory L. Holmes5Epilepsy Development and Cognition Group, Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, USAEpilepsy Development and Cognition Group, Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, USAEpilepsy Development and Cognition Group, Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, USAEpilepsy Development and Cognition Group, Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, USAEpilepsy Development and Cognition Group, Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, USACorresponding author at: University of Vermont College of Medicine, 95 Carrigan Drive, Neurological Sciences - Stafford 118, Burlington, VT 05405, USA.; Epilepsy Development and Cognition Group, Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, USAThere is increasing human and animal evidence that brain oscillations play a critical role in the development of spatial cognition. In rat pups, disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition. Early-life seizures are associated with long-term deficits in spatial cognition and aberrant hippocampal oscillatory activity. Here we asked whether modulation of hippocampal rhythms following early-life seizures can reverse or improve hippocampal connectivity and spatial cognition. We used optogenetic stimulation of the medial septum to induce physiological 7 Hz theta oscillations in the hippocampus during the critical period of spatial cognition following early-life seizures.Optogenetic stimulation of the medial septum in control and rats subjected to early-life seizures resulted in precisely regulated frequency-matched hippocampal oscillations. Rat pups receiving active blue light stimulation performed better than the rats receiving inert yellow light in a test of spatial cognition. The improvement in spatial cognition in these rats was associated with a faster theta frequency and higher theta power, coherence and phase locking value in the hippocampus than rats with early-life seizures receiving inert yellow light. These findings indicate that following early life seizures, modification of hippocampal rhythms may be a potential novel therapeutic modality.http://www.sciencedirect.com/science/article/pii/S0969996123000359EpilepsySeizuresCognitionOptogeneticsThetaDysrhythmia |
| spellingShingle | Francisco Velasquez Conor Dickson Michelle L. Kloc Carmel A. Schneur Jeremy M. Barry Gregory L. Holmes Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures Neurobiology of Disease Epilepsy Seizures Cognition Optogenetics Theta Dysrhythmia |
| title | Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures |
| title_full | Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures |
| title_fullStr | Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures |
| title_full_unstemmed | Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures |
| title_short | Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures |
| title_sort | optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early life seizures |
| topic | Epilepsy Seizures Cognition Optogenetics Theta Dysrhythmia |
| url | http://www.sciencedirect.com/science/article/pii/S0969996123000359 |
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