Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures

Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures

There is increasing human and animal evidence that brain oscillations play a critical role in the development of spatial cognition. In rat pups, disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition. Early-life seizu...

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Bibliographic Details
Main Authors:	Francisco Velasquez, Conor Dickson, Michelle L. Kloc, Carmel A. Schneur, Jeremy M. Barry, Gregory L. Holmes
Format:	Article
Language:	English
Published:	Elsevier 2023-03-01
Series:	Neurobiology of Disease
Subjects:	Epilepsy Seizures Cognition Optogenetics Theta Dysrhythmia
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996123000359

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