Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance
Dissociated optic nerve fiber layer (DONFL) appearance is characterized by dimpling of the fundus when observed after vitrectomy with the internal limiting membrane (ILM) peeling in macular diseases. However, the cause of DONFL remains largely unknown. Optical coherence tomography (OCT) findings hav...
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/4/1724 |
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| author | Tsunehiko Ikeda Kimitoshi Nakamura Takaki Sato Teruyo Kida Hidehiro Oku |
| author_facet | Tsunehiko Ikeda Kimitoshi Nakamura Takaki Sato Teruyo Kida Hidehiro Oku |
| author_sort | Tsunehiko Ikeda |
| collection | DOAJ |
| description | Dissociated optic nerve fiber layer (DONFL) appearance is characterized by dimpling of the fundus when observed after vitrectomy with the internal limiting membrane (ILM) peeling in macular diseases. However, the cause of DONFL remains largely unknown. Optical coherence tomography (OCT) findings have indicated that the nerve fiber layer (NFL) and ganglion cells are likely to have been damaged in patients with DONFL appearance. Since DONFL appearance occurs at a certain postoperative period, it is unlikely to be retinal damage directly caused by ILM peeling because apoptosis occurs at a certain period after tissue damage and/or injury. However, it may be due to ILM peeling-induced apoptosis in the retinal tissue. Anoikis is a type of apoptosis that occurs in anchorage-dependent cells upon detachment of those cells from the surrounding extracellular matrix (i.e., the loss of cell anchorage). The anoikis-related proteins βA3/A1 crystallin and E-cadherin are reportedly expressed in retinal ganglion cells. Thus, we theorize that one possible cause of DONFL appearance is ILM peeling-induced anoikis in retinal ganglion cells. |
| first_indexed | 2024-03-09T05:01:31Z |
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| id | doaj.art-d9405947b37d4b3dba7ab0f696297c38 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:01:31Z |
| publishDate | 2021-02-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d9405947b37d4b3dba7ab0f696297c382023-12-03T12:59:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224172410.3390/ijms22041724Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer AppearanceTsunehiko Ikeda0Kimitoshi Nakamura1Takaki Sato2Teruyo Kida3Hidehiro Oku4Department of Ophthalmology, Osaka Medical College, Takatsuki-City 569-8686, Osaka, JapanNakamura Eye Clinic, Matsumoto-City 390-0811, Nagano, JapanDepartment of Ophthalmology, Osaka Medical College, Takatsuki-City 569-8686, Osaka, JapanDepartment of Ophthalmology, Osaka Medical College, Takatsuki-City 569-8686, Osaka, JapanDepartment of Ophthalmology, Osaka Medical College, Takatsuki-City 569-8686, Osaka, JapanDissociated optic nerve fiber layer (DONFL) appearance is characterized by dimpling of the fundus when observed after vitrectomy with the internal limiting membrane (ILM) peeling in macular diseases. However, the cause of DONFL remains largely unknown. Optical coherence tomography (OCT) findings have indicated that the nerve fiber layer (NFL) and ganglion cells are likely to have been damaged in patients with DONFL appearance. Since DONFL appearance occurs at a certain postoperative period, it is unlikely to be retinal damage directly caused by ILM peeling because apoptosis occurs at a certain period after tissue damage and/or injury. However, it may be due to ILM peeling-induced apoptosis in the retinal tissue. Anoikis is a type of apoptosis that occurs in anchorage-dependent cells upon detachment of those cells from the surrounding extracellular matrix (i.e., the loss of cell anchorage). The anoikis-related proteins βA3/A1 crystallin and E-cadherin are reportedly expressed in retinal ganglion cells. Thus, we theorize that one possible cause of DONFL appearance is ILM peeling-induced anoikis in retinal ganglion cells.https://www.mdpi.com/1422-0067/22/4/1724macular hole (MH)vitrectomyinternal limiting membrane (ILM)dissociated optic nerve fiber layer (DONFL)optical coherence tomography (OCT)anoikis |
| spellingShingle | Tsunehiko Ikeda Kimitoshi Nakamura Takaki Sato Teruyo Kida Hidehiro Oku Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance International Journal of Molecular Sciences macular hole (MH) vitrectomy internal limiting membrane (ILM) dissociated optic nerve fiber layer (DONFL) optical coherence tomography (OCT) anoikis |
| title | Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance |
| title_full | Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance |
| title_fullStr | Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance |
| title_full_unstemmed | Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance |
| title_short | Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance |
| title_sort | involvement of anoikis in dissociated optic nerve fiber layer appearance |
| topic | macular hole (MH) vitrectomy internal limiting membrane (ILM) dissociated optic nerve fiber layer (DONFL) optical coherence tomography (OCT) anoikis |
| url | https://www.mdpi.com/1422-0067/22/4/1724 |
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