The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial
Background: Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons. Objective: The objective of the current study was to determine the impacts of vitamin E and aspirin on...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2017-12-01
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| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-286&slc_lang=en&sid=1 |
| _version_ | 1818126312369291264 |
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| author | Elaheh Mesdaghinia Behnaz Mohammad-Ebrahimi Fatemeh Foroozanfard Hamid Reza Banafshe |
| author_facet | Elaheh Mesdaghinia Behnaz Mohammad-Ebrahimi Fatemeh Foroozanfard Hamid Reza Banafshe |
| author_sort | Elaheh Mesdaghinia |
| collection | DOAJ |
| description | Background: Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons. Objective: The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood flow. Materials and Methods: This randomized clinical trial was conducted on 99 women having uterine pulsatility index (PI) more than 2.5 and the history of more than two times abortions. The candidates were categorized into three groups; receiving aspirin, only vitamin E, and aspirin+vitamin E. After 2 months, uterine PIs were compared with each other. Results: All drug regimens caused an enhancement in uterine perfusion with a significant decline in uterine artery PI value. The women receiving vitamin E in accompanied with aspirin had the least mean PI of the uterine artery (p<0.001). The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0.001). Conclusion: Vitamin E, aspirin and especially their combination are effective in improving uterine artery blood flow in women with recurrent abortion due to impaired uterine blood flow. More well-designed studies are needed to find out whether the enhancement of uterine perfusion may lead to a better pregnancy outcome. |
| first_indexed | 2024-12-11T06:59:28Z |
| format | Article |
| id | doaj.art-d9405cec19bd4ff38d56b69375b46bfa |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-12-11T06:59:28Z |
| publishDate | 2017-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-d9405cec19bd4ff38d56b69375b46bfa2022-12-22T01:16:39ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722017-12-011510635640The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trialElaheh Mesdaghinia0Behnaz Mohammad-Ebrahimi1Fatemeh Foroozanfard2Hamid Reza Banafshe3 Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran. Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran Background: Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons. Objective: The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood flow. Materials and Methods: This randomized clinical trial was conducted on 99 women having uterine pulsatility index (PI) more than 2.5 and the history of more than two times abortions. The candidates were categorized into three groups; receiving aspirin, only vitamin E, and aspirin+vitamin E. After 2 months, uterine PIs were compared with each other. Results: All drug regimens caused an enhancement in uterine perfusion with a significant decline in uterine artery PI value. The women receiving vitamin E in accompanied with aspirin had the least mean PI of the uterine artery (p<0.001). The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0.001). Conclusion: Vitamin E, aspirin and especially their combination are effective in improving uterine artery blood flow in women with recurrent abortion due to impaired uterine blood flow. More well-designed studies are needed to find out whether the enhancement of uterine perfusion may lead to a better pregnancy outcome.http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-286&slc_lang=en&sid=1Recurrent abortion Aspirin Vitamin E Pulsatility index |
| spellingShingle | Elaheh Mesdaghinia Behnaz Mohammad-Ebrahimi Fatemeh Foroozanfard Hamid Reza Banafshe The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial International Journal of Reproductive BioMedicine Recurrent abortion Aspirin Vitamin E Pulsatility index |
| title | The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial |
| title_full | The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial |
| title_fullStr | The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial |
| title_full_unstemmed | The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial |
| title_short | The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial |
| title_sort | effect of vitamin e and aspirin on the uterine artery blood flow in women with recurrent abortion a single blind randomized controlled trial |
| topic | Recurrent abortion Aspirin Vitamin E Pulsatility index |
| url | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-286&slc_lang=en&sid=1 |
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