Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity
Autophagy is a conserved cellular mechanism that enables the degradation and recycling of cellular organelles and proteins via the lysosomal pathway. In neurodevelopment and maintenance of neuronal homeostasis, autophagy is required to regulate presynaptic functions, synapse remodeling, and synaptic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322842/full |
| _version_ | 1797300181833613312 |
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| author | Isaac Bai Cameron Keyser Ziyan Zhang Breandan Rosolia Jee-Yeon Hwang R. Suzanne Zukin Jingqi Yan |
| author_facet | Isaac Bai Cameron Keyser Ziyan Zhang Breandan Rosolia Jee-Yeon Hwang R. Suzanne Zukin Jingqi Yan |
| author_sort | Isaac Bai |
| collection | DOAJ |
| description | Autophagy is a conserved cellular mechanism that enables the degradation and recycling of cellular organelles and proteins via the lysosomal pathway. In neurodevelopment and maintenance of neuronal homeostasis, autophagy is required to regulate presynaptic functions, synapse remodeling, and synaptic plasticity. Deficiency of autophagy has been shown to underlie the synaptic and behavioral deficits of many neurological diseases such as autism, psychiatric diseases, and neurodegenerative disorders. Recent evidence reveals that dysregulated autophagy plays an important role in the initiation and progression of neuroinflammation, a common pathological feature in many neurological disorders leading to defective synaptic morphology and plasticity. In this review, we will discuss the regulation of autophagy and its effects on synapses and neuroinflammation, with emphasis on how autophagy is regulated by epigenetic mechanisms under healthy and diseased conditions. |
| first_indexed | 2024-03-07T23:03:35Z |
| format | Article |
| id | doaj.art-d94128eb929f472b8d142513d2f9c454 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T23:03:35Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d94128eb929f472b8d142513d2f9c4542024-02-22T09:24:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13228421322842Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticityIsaac Bai0Cameron Keyser1Ziyan Zhang2Breandan Rosolia3Jee-Yeon Hwang4R. Suzanne Zukin5Jingqi Yan6Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH, United StatesCenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH, United StatesCenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH, United StatesCenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH, United StatesDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, United StatesDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY, United StatesCenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH, United StatesAutophagy is a conserved cellular mechanism that enables the degradation and recycling of cellular organelles and proteins via the lysosomal pathway. In neurodevelopment and maintenance of neuronal homeostasis, autophagy is required to regulate presynaptic functions, synapse remodeling, and synaptic plasticity. Deficiency of autophagy has been shown to underlie the synaptic and behavioral deficits of many neurological diseases such as autism, psychiatric diseases, and neurodegenerative disorders. Recent evidence reveals that dysregulated autophagy plays an important role in the initiation and progression of neuroinflammation, a common pathological feature in many neurological disorders leading to defective synaptic morphology and plasticity. In this review, we will discuss the regulation of autophagy and its effects on synapses and neuroinflammation, with emphasis on how autophagy is regulated by epigenetic mechanisms under healthy and diseased conditions.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322842/fullautophagyepigeneticsneuroinflammationmicrogliasynapse |
| spellingShingle | Isaac Bai Cameron Keyser Ziyan Zhang Breandan Rosolia Jee-Yeon Hwang R. Suzanne Zukin Jingqi Yan Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity Frontiers in Immunology autophagy epigenetics neuroinflammation microglia synapse |
| title | Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity |
| title_full | Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity |
| title_fullStr | Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity |
| title_full_unstemmed | Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity |
| title_short | Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity |
| title_sort | epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity |
| topic | autophagy epigenetics neuroinflammation microglia synapse |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322842/full |
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