Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients.
This single-institution cross-sectional study aimed to grasp the prevalence and features of neurocognitive dysfunction in HIV-infected hemophilia patients in Japan. We conducted neuropsychological tests and medical examinations in 56 HIV-infected hemophilia patients who received outpatient treatment...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0230292 |
| _version_ | 1818833556659503104 |
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| author | Koubun Imai Sota Kimura Yoko Kiryu Aki Watanabe Ei Kinai Shinichi Oka Yoshimi Kikuchi Satoshi Kimura Mikiko Ogata Misao Takano Ryogo Minamimoto Masatoshi Hotta Kota Yokoyama Tomoyuki Noguchi Kensuke Komatsu |
| author_facet | Koubun Imai Sota Kimura Yoko Kiryu Aki Watanabe Ei Kinai Shinichi Oka Yoshimi Kikuchi Satoshi Kimura Mikiko Ogata Misao Takano Ryogo Minamimoto Masatoshi Hotta Kota Yokoyama Tomoyuki Noguchi Kensuke Komatsu |
| author_sort | Koubun Imai |
| collection | DOAJ |
| description | This single-institution cross-sectional study aimed to grasp the prevalence and features of neurocognitive dysfunction in HIV-infected hemophilia patients in Japan. We conducted neuropsychological tests and medical examinations in 56 HIV-infected hemophilia patients who received outpatient treatment at the AIDS Clinical Center, National Center for Global Health and Medicine. A total of 388 HIV-infected non-hemophilia patients who received outpatient treatment at the same institution were included as a control group. To investigate sites responsible for neurocognitive dysfunction in HIV-infected hemophilia patients using brain FDG-PET/CT scans, the accumulation of FDG in each brain region was compared. Approximately 50% of HIV-infected hemophilia patients had neurocognitive dysfunction. The prevalence of asymptomatic neurocognitive impairment was high (34%). Neurocognitive dysfunction was associated with educational level in HIV-infected hemophilia patients. In the symptomatic group, hemophilic arthropathy and history of cerebrovascular disorders were associated with neurocognitive dysfunction. Left temporal lobe function was reduced in the symptomatic group. |
| first_indexed | 2024-12-19T02:20:48Z |
| format | Article |
| id | doaj.art-d941c5dd5e8343cca15bf668ff0bf701 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T02:20:48Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d941c5dd5e8343cca15bf668ff0bf7012022-12-21T20:40:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01153e023029210.1371/journal.pone.0230292Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients.Koubun ImaiSota KimuraYoko KiryuAki WatanabeEi KinaiShinichi OkaYoshimi KikuchiSatoshi KimuraMikiko OgataMisao TakanoRyogo MinamimotoMasatoshi HottaKota YokoyamaTomoyuki NoguchiKensuke KomatsuThis single-institution cross-sectional study aimed to grasp the prevalence and features of neurocognitive dysfunction in HIV-infected hemophilia patients in Japan. We conducted neuropsychological tests and medical examinations in 56 HIV-infected hemophilia patients who received outpatient treatment at the AIDS Clinical Center, National Center for Global Health and Medicine. A total of 388 HIV-infected non-hemophilia patients who received outpatient treatment at the same institution were included as a control group. To investigate sites responsible for neurocognitive dysfunction in HIV-infected hemophilia patients using brain FDG-PET/CT scans, the accumulation of FDG in each brain region was compared. Approximately 50% of HIV-infected hemophilia patients had neurocognitive dysfunction. The prevalence of asymptomatic neurocognitive impairment was high (34%). Neurocognitive dysfunction was associated with educational level in HIV-infected hemophilia patients. In the symptomatic group, hemophilic arthropathy and history of cerebrovascular disorders were associated with neurocognitive dysfunction. Left temporal lobe function was reduced in the symptomatic group.https://doi.org/10.1371/journal.pone.0230292 |
| spellingShingle | Koubun Imai Sota Kimura Yoko Kiryu Aki Watanabe Ei Kinai Shinichi Oka Yoshimi Kikuchi Satoshi Kimura Mikiko Ogata Misao Takano Ryogo Minamimoto Masatoshi Hotta Kota Yokoyama Tomoyuki Noguchi Kensuke Komatsu Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients. PLoS ONE |
| title | Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients. |
| title_full | Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients. |
| title_fullStr | Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients. |
| title_full_unstemmed | Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients. |
| title_short | Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients. |
| title_sort | neurocognitive dysfunction and brain fdg pet ct findings in hiv infected hemophilia patients and hiv infected non hemophilia patients |
| url | https://doi.org/10.1371/journal.pone.0230292 |
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