Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
Abstract Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted f...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-87809-4 |
| _version_ | 1818424835958636544 |
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| author | Ming Wang Gwangho Yoon Juhyun Song Jihoon Jo |
| author_facet | Ming Wang Gwangho Yoon Juhyun Song Jihoon Jo |
| author_sort | Ming Wang |
| collection | DOAJ |
| description | Abstract Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted from gut L-cells and specific brain nuclei plays multiple roles including regulation of insulin sensitivity, inflammation and synaptic plasticity. Although GLP-1 and GLP-1 receptor agonists appear to have neuroprotective function, the specific mechanism of their action in brain remains unclear. We investigated whether exendin-4, as a GLP-1RA, improves cognitive function and brain insulin resistance in metabolic-imbalanced mice fed a high-fat diet. Considering the result of electrophysiological experiments, exendin-4 inhibits the reduction of long term potentiation (LTP) in high fat diet mouse brain. Further, we identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons in in vitro metabolic imbalanced condition. Our results showed the improvement of IRS-1 phosphorylation, neuronal complexity, and the mature of dendritic spine shape by exendin-4 treatment in metabolic imbalanced in vitro condition. Here, we provides significant evidences on the effect of exendin-4 on synaptic plasticity, long-term potentiation, and neural structure. We suggest that GLP-1 is important to treat neuropathology caused by metabolic syndrome. |
| first_indexed | 2024-12-14T14:04:22Z |
| format | Article |
| id | doaj.art-d943b03039be4c6d9379d30b950d4ed8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T14:04:22Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d943b03039be4c6d9379d30b950d4ed82022-12-21T22:58:37ZengNature PortfolioScientific Reports2045-23222021-04-0111111410.1038/s41598-021-87809-4Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity conditionMing Wang0Gwangho Yoon1Juhyun Song2Jihoon Jo3BioMedical Sciences Graduate Program (BMSGP), Chonnam National UniversityBioMedical Sciences Graduate Program (BMSGP), Chonnam National UniversityBioMedical Sciences Graduate Program (BMSGP), Chonnam National UniversityBioMedical Sciences Graduate Program (BMSGP), Chonnam National UniversityAbstract Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted from gut L-cells and specific brain nuclei plays multiple roles including regulation of insulin sensitivity, inflammation and synaptic plasticity. Although GLP-1 and GLP-1 receptor agonists appear to have neuroprotective function, the specific mechanism of their action in brain remains unclear. We investigated whether exendin-4, as a GLP-1RA, improves cognitive function and brain insulin resistance in metabolic-imbalanced mice fed a high-fat diet. Considering the result of electrophysiological experiments, exendin-4 inhibits the reduction of long term potentiation (LTP) in high fat diet mouse brain. Further, we identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons in in vitro metabolic imbalanced condition. Our results showed the improvement of IRS-1 phosphorylation, neuronal complexity, and the mature of dendritic spine shape by exendin-4 treatment in metabolic imbalanced in vitro condition. Here, we provides significant evidences on the effect of exendin-4 on synaptic plasticity, long-term potentiation, and neural structure. We suggest that GLP-1 is important to treat neuropathology caused by metabolic syndrome.https://doi.org/10.1038/s41598-021-87809-4 |
| spellingShingle | Ming Wang Gwangho Yoon Juhyun Song Jihoon Jo Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition Scientific Reports |
| title | Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition |
| title_full | Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition |
| title_fullStr | Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition |
| title_full_unstemmed | Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition |
| title_short | Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition |
| title_sort | exendin 4 improves long term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition |
| url | https://doi.org/10.1038/s41598-021-87809-4 |
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