Chalcone-Acridine Hybrid Suppresses Melanoma Cell Progression via G2/M Cell Cycle Arrest, DNA Damage, Apoptosis, and Modulation of MAP Kinases Activity

Chalcone-Acridine Hybrid Suppresses Melanoma Cell Progression via G2/M Cell Cycle Arrest, DNA Damage, Apoptosis, and Modulation of MAP Kinases Activity

This study was focused on investigating the antiproliferative effects of chalcone hybrids in melanoma cancer cells. Among seven chalcone hybrids, the chalcone-acridine hybrid <b>1C</b> was the most potent and was selected for further antiproliferative mechanism studies. This in vitro stu...

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Bibliographic Details
Main Authors: Maria Gazdova, Radka Michalkova, Martin Kello, Maria Vilkova, Zuzana Kudlickova, Janette Baloghova, Ladislav Mirossay, Jan Mojzis
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
chalcone-acridine hybrid
apoptosis
cell cycle arrest
DNA damage
MAP kinases
Online Access:https://www.mdpi.com/1422-0067/23/20/12266

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