Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic Fibrosis
Background. The clinical relevance of Aspergillus fumigatus (Af) in cystic fibrosis (CF) is controversial. The aims of the study were to assess the prevalence of Af disease in our cohort of CF patients and evaluate whether allergic bronchopulmonary aspergillosis (ABPA) and sensitization to Af affect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/4/739 |
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| author | Valentina Fainardi Chiara Sodini Michela Deolmi Andrea Ciuni Kaltra Skenderaj Maria Bice Stabile Cosimo Neglia Elena Mariotti Zani Cinzia Spaggiari Nicola Sverzellati Susanna Esposito Giovanna Pisi |
| author_facet | Valentina Fainardi Chiara Sodini Michela Deolmi Andrea Ciuni Kaltra Skenderaj Maria Bice Stabile Cosimo Neglia Elena Mariotti Zani Cinzia Spaggiari Nicola Sverzellati Susanna Esposito Giovanna Pisi |
| author_sort | Valentina Fainardi |
| collection | DOAJ |
| description | Background. The clinical relevance of Aspergillus fumigatus (Af) in cystic fibrosis (CF) is controversial. The aims of the study were to assess the prevalence of Af disease in our cohort of CF patients and evaluate whether allergic bronchopulmonary aspergillosis (ABPA) and sensitization to Af affected lung function, body mass index (BMI) and exacerbations. Methods. Clinical data and lung function of CF patients aged 6–18 years followed at the CF Centre of Parma (Italy) were recorded. Patients were classified as: patients with no signs of Af, patients sensitized or colonized by Af, patients with ABPA or patients with Aspergillus bronchitis (Ab). Results. Of 38 CF patients (14.2 years (6.2–18.8) M 23), 8 (21%) showed Af sensitization, 7 (18.4%) showed ABPA, 1 (2.6%) showed Af colonization and 1 (2.6%) showed Ab. Compared to non-ABPA, patients with ABPA had lower BMI (15.9 ± 1.6 vs. 19.7 ± 3.4, <i>p</i> < 0.005), lower lung function (FEV<sub>1</sub> 61.5 ± 25.9% vs. 92.3 ± 19.3%, <i>p</i> < 0.001) and more exacerbations/year (4.43 ± 2.44 vs. 1.74 ± 2.33, <i>p</i> < 0.005). Patients with Af sensitization showed more exacerbations/year than non-Af patients (3.5 ± 3.2 vs. 0.9 ± 1.2, <i>p</i> < 0.005). ABPA and sensitized patients had more abnormalities on chest CT scans. Conclusion. This study showed the relevant clinical impact of ABPA and Af sensitization in terms of exacerbations and lung structural damage. |
| first_indexed | 2024-03-09T13:16:52Z |
| format | Article |
| id | doaj.art-d946b89da14c4cc9846c1a1e34ed63a4 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T13:16:52Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d946b89da14c4cc9846c1a1e34ed63a42023-11-30T21:35:06ZengMDPI AGMicroorganisms2076-26072022-03-0110473910.3390/microorganisms10040739Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic FibrosisValentina Fainardi0Chiara Sodini1Michela Deolmi2Andrea Ciuni3Kaltra Skenderaj4Maria Bice Stabile5Cosimo Neglia6Elena Mariotti Zani7Cinzia Spaggiari8Nicola Sverzellati9Susanna Esposito10Giovanna Pisi11Cystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyScienze Radiologiche, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyScienze Radiologiche, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCystic Fibrosis Unit, Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyBackground. The clinical relevance of Aspergillus fumigatus (Af) in cystic fibrosis (CF) is controversial. The aims of the study were to assess the prevalence of Af disease in our cohort of CF patients and evaluate whether allergic bronchopulmonary aspergillosis (ABPA) and sensitization to Af affected lung function, body mass index (BMI) and exacerbations. Methods. Clinical data and lung function of CF patients aged 6–18 years followed at the CF Centre of Parma (Italy) were recorded. Patients were classified as: patients with no signs of Af, patients sensitized or colonized by Af, patients with ABPA or patients with Aspergillus bronchitis (Ab). Results. Of 38 CF patients (14.2 years (6.2–18.8) M 23), 8 (21%) showed Af sensitization, 7 (18.4%) showed ABPA, 1 (2.6%) showed Af colonization and 1 (2.6%) showed Ab. Compared to non-ABPA, patients with ABPA had lower BMI (15.9 ± 1.6 vs. 19.7 ± 3.4, <i>p</i> < 0.005), lower lung function (FEV<sub>1</sub> 61.5 ± 25.9% vs. 92.3 ± 19.3%, <i>p</i> < 0.001) and more exacerbations/year (4.43 ± 2.44 vs. 1.74 ± 2.33, <i>p</i> < 0.005). Patients with Af sensitization showed more exacerbations/year than non-Af patients (3.5 ± 3.2 vs. 0.9 ± 1.2, <i>p</i> < 0.005). ABPA and sensitized patients had more abnormalities on chest CT scans. Conclusion. This study showed the relevant clinical impact of ABPA and Af sensitization in terms of exacerbations and lung structural damage.https://www.mdpi.com/2076-2607/10/4/739cystic fibrosisAspergillusABPAlung functionchest CTfungal infection |
| spellingShingle | Valentina Fainardi Chiara Sodini Michela Deolmi Andrea Ciuni Kaltra Skenderaj Maria Bice Stabile Cosimo Neglia Elena Mariotti Zani Cinzia Spaggiari Nicola Sverzellati Susanna Esposito Giovanna Pisi Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic Fibrosis Microorganisms cystic fibrosis Aspergillus ABPA lung function chest CT fungal infection |
| title | Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic Fibrosis |
| title_full | Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic Fibrosis |
| title_fullStr | Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic Fibrosis |
| title_full_unstemmed | Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic Fibrosis |
| title_short | Clinical Impact of <i>Aspergillus fumigatus</i> in Children with Cystic Fibrosis |
| title_sort | clinical impact of i aspergillus fumigatus i in children with cystic fibrosis |
| topic | cystic fibrosis Aspergillus ABPA lung function chest CT fungal infection |
| url | https://www.mdpi.com/2076-2607/10/4/739 |
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