The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis
Psoriasis is a common genetic autoimmune disorder with a global prevalence of 2–3%. The clear pathogenesis of psoriasis is not fully understood, but hyperproliferation and inflammation of the epidermis with marked infiltration of immune cells have been indicated in psoriasis with such cells producin...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Dermato |
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| Online Access: | https://www.mdpi.com/2673-6179/3/1/2 |
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| author | Keshav Kc Hua Hu Tilak Mahatara Sunil Koirala Samjhana Shrestha Shiv K. Sharma Xiangfeng Song Zhongwei Tian |
| author_facet | Keshav Kc Hua Hu Tilak Mahatara Sunil Koirala Samjhana Shrestha Shiv K. Sharma Xiangfeng Song Zhongwei Tian |
| author_sort | Keshav Kc |
| collection | DOAJ |
| description | Psoriasis is a common genetic autoimmune disorder with a global prevalence of 2–3%. The clear pathogenesis of psoriasis is not fully understood, but hyperproliferation and inflammation of the epidermis with marked infiltration of immune cells have been indicated in psoriasis with such cells producing different types of cytokines- interleukin. As such a new member of the IL-1 cytokine family, in some research, IL-33 has been linked with psoriasis showing high serum concentration of IL-33 in human psoriatic plaques compared to normal healthy skin. Despite this, the association between IL-33 and psoriasis is not clear. Herein, in this review, we aim to investigate the correlation between serum IL-33 levels and psoriasis. We conducted meta-analysis using fixed or random-effects models to calculate pooled standard mean differences. We found that the mean IL-33 serum levels were reported between 0.35 pg/mL to 586 pg/mL in the psoriatic group and 0 pg/mL to 87.7 pg/mL in the healthy control group. Out of five, four individual studies included in the analysis reported statistically significant differences in IL-33 levels, the pooled estimate (SMD = 0.340 95% CI: −0.308 to 0.988), however, did not indicate a significant relation between IL-33 and psoriasis. This analysis revealed no significant difference between serum IL-33 levels in the psoriatic population in comparison to healthy controls. This may be because we did not include any animal studies, lab-based studies, any other markers mixed together, or any other cases of diseases mixed together. However, further research is warranted to confirm the reported association as this analysis is limited by the low-quality and observational nature of the included studies. |
| first_indexed | 2024-03-11T06:42:14Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2673-6179 |
| language | English |
| last_indexed | 2024-03-11T06:42:14Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermato |
| spelling | doaj.art-d947003997d94cb3aa70a6d298d71a9b2023-11-17T10:32:33ZengMDPI AGDermato2673-61792023-01-0131132410.3390/dermato3010002The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-AnalysisKeshav Kc0Hua Hu1Tilak Mahatara2Sunil Koirala3Samjhana Shrestha4Shiv K. Sharma5Xiangfeng Song6Zhongwei Tian7Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, ChinaDepartment of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, ChinaSchool of Health and Allied Sciences, Faculty of Health Sciences, Pokhara University, Pokhara 33700, NepalSchool of Health and Allied Sciences, Faculty of Health Sciences, Pokhara University, Pokhara 33700, NepalHealth Research Institute, Faculty of Health, University of Canberra, Bruce, ACT 2617, AustraliaDepartment of Chemistry, Thomas More University, 333 Thomas More Pkwy, Crestview Hills, KY 41017, USADepartment of Immunology, Xinxiang Medical University, Xinxiang 453000, ChinaDepartment of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, ChinaPsoriasis is a common genetic autoimmune disorder with a global prevalence of 2–3%. The clear pathogenesis of psoriasis is not fully understood, but hyperproliferation and inflammation of the epidermis with marked infiltration of immune cells have been indicated in psoriasis with such cells producing different types of cytokines- interleukin. As such a new member of the IL-1 cytokine family, in some research, IL-33 has been linked with psoriasis showing high serum concentration of IL-33 in human psoriatic plaques compared to normal healthy skin. Despite this, the association between IL-33 and psoriasis is not clear. Herein, in this review, we aim to investigate the correlation between serum IL-33 levels and psoriasis. We conducted meta-analysis using fixed or random-effects models to calculate pooled standard mean differences. We found that the mean IL-33 serum levels were reported between 0.35 pg/mL to 586 pg/mL in the psoriatic group and 0 pg/mL to 87.7 pg/mL in the healthy control group. Out of five, four individual studies included in the analysis reported statistically significant differences in IL-33 levels, the pooled estimate (SMD = 0.340 95% CI: −0.308 to 0.988), however, did not indicate a significant relation between IL-33 and psoriasis. This analysis revealed no significant difference between serum IL-33 levels in the psoriatic population in comparison to healthy controls. This may be because we did not include any animal studies, lab-based studies, any other markers mixed together, or any other cases of diseases mixed together. However, further research is warranted to confirm the reported association as this analysis is limited by the low-quality and observational nature of the included studies.https://www.mdpi.com/2673-6179/3/1/2serum IL-33psoriasissystematic reviewmeta-analysis |
| spellingShingle | Keshav Kc Hua Hu Tilak Mahatara Sunil Koirala Samjhana Shrestha Shiv K. Sharma Xiangfeng Song Zhongwei Tian The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis Dermato serum IL-33 psoriasis systematic review meta-analysis |
| title | The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis |
| title_full | The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis |
| title_fullStr | The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis |
| title_short | The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis |
| title_sort | correlation between interleukin 33 and psoriasis a systematic review and meta analysis |
| topic | serum IL-33 psoriasis systematic review meta-analysis |
| url | https://www.mdpi.com/2673-6179/3/1/2 |
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