Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> Shape
The versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2221-3759/8/1/7 |
| _version_ | 1819108761855328256 |
|---|---|
| author | Cátia A. Carvalho Limor Broday |
| author_facet | Cátia A. Carvalho Limor Broday |
| author_sort | Cátia A. Carvalho |
| collection | DOAJ |
| description | The versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these cells are central to multicellularity, and participate in diverse biological processes such as organismal development, growth or immune response and their misfunction ultimately impacts disease. During the development of an organism, the first task epidermal cells must complete is the formation of a continuous sheet, which initiates its own morphogenic process. In this review, we will focus on the <i>C. elegans</i> embryonic epithelial morphogenesis. We will describe how its formation, maturation, and spatial arrangements set the final shape of the nematode <i>C. elegans</i>. Special importance will be given to the tissue-tissue interactions, regulatory tissue-tissue feedback mechanisms and the players orchestrating the process. |
| first_indexed | 2024-12-22T03:15:04Z |
| format | Article |
| id | doaj.art-d94863c31cc947d88aa0ce3713d29699 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-12-22T03:15:04Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-d94863c31cc947d88aa0ce3713d296992022-12-21T18:40:50ZengMDPI AGJournal of Developmental Biology2221-37592020-03-0181710.3390/jdb8010007jdb8010007Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> ShapeCátia A. Carvalho0Limor Broday1Department of Cell and Developmental Biology, School of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelDepartment of Cell and Developmental Biology, School of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelThe versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these cells are central to multicellularity, and participate in diverse biological processes such as organismal development, growth or immune response and their misfunction ultimately impacts disease. During the development of an organism, the first task epidermal cells must complete is the formation of a continuous sheet, which initiates its own morphogenic process. In this review, we will focus on the <i>C. elegans</i> embryonic epithelial morphogenesis. We will describe how its formation, maturation, and spatial arrangements set the final shape of the nematode <i>C. elegans</i>. Special importance will be given to the tissue-tissue interactions, regulatory tissue-tissue feedback mechanisms and the players orchestrating the process.https://www.mdpi.com/2221-3759/8/1/7epithelial morphogenesisepidermal-neuroblast axisepidermal-muscle axis<i>c. elegans</i> |
| spellingShingle | Cátia A. Carvalho Limor Broday Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> Shape Journal of Developmental Biology epithelial morphogenesis epidermal-neuroblast axis epidermal-muscle axis <i>c. elegans</i> |
| title | Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> Shape |
| title_full | Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> Shape |
| title_fullStr | Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> Shape |
| title_full_unstemmed | Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> Shape |
| title_short | Game of Tissues: How the Epidermis Thrones <i>C. elegans</i> Shape |
| title_sort | game of tissues how the epidermis thrones i c elegans i shape |
| topic | epithelial morphogenesis epidermal-neuroblast axis epidermal-muscle axis <i>c. elegans</i> |
| url | https://www.mdpi.com/2221-3759/8/1/7 |
| work_keys_str_mv | AT catiaacarvalho gameoftissueshowtheepidermisthronesicelegansishape AT limorbroday gameoftissueshowtheepidermisthronesicelegansishape |