On-Chip Liquid Chromatography
On-chip liquid chromatography (LC) refers to LC technology that is miniaturized to fit on a microchip to enable fast, high-throughput analysis, with small sample volumes and low reagent consumption. Four different on-chip LC approaches have been developed to date: use of open-tubular, packed-particl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Encyclopedia |
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| Online Access: | https://www.mdpi.com/2673-8392/2/1/41 |
| _version_ | 1827649275206565888 |
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| author | Makoto Tsunoda |
| author_facet | Makoto Tsunoda |
| author_sort | Makoto Tsunoda |
| collection | DOAJ |
| description | On-chip liquid chromatography (LC) refers to LC technology that is miniaturized to fit on a microchip to enable fast, high-throughput analysis, with small sample volumes and low reagent consumption. Four different on-chip LC approaches have been developed to date: use of open-tubular, packed-particle, monolithic, and pillar array columns. These methods have been applied to proteomics as well as the analysis of small molecules and drugs in various biological samples. Recent advances in on-chip LC are summarized herein. |
| first_indexed | 2024-03-09T19:54:31Z |
| format | Article |
| id | doaj.art-d94ad784075444fdabde74a7472e31d6 |
| institution | Directory Open Access Journal |
| issn | 2673-8392 |
| language | English |
| last_indexed | 2024-03-09T19:54:31Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Encyclopedia |
| spelling | doaj.art-d94ad784075444fdabde74a7472e31d62023-11-24T01:01:55ZengMDPI AGEncyclopedia2673-83922022-03-012161762410.3390/encyclopedia2010041On-Chip Liquid ChromatographyMakoto Tsunoda0Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 1130033, JapanOn-chip liquid chromatography (LC) refers to LC technology that is miniaturized to fit on a microchip to enable fast, high-throughput analysis, with small sample volumes and low reagent consumption. Four different on-chip LC approaches have been developed to date: use of open-tubular, packed-particle, monolithic, and pillar array columns. These methods have been applied to proteomics as well as the analysis of small molecules and drugs in various biological samples. Recent advances in on-chip LC are summarized herein.https://www.mdpi.com/2673-8392/2/1/41micro total analysis systemopen tubularpacked particlemonolithicpillar array |
| spellingShingle | Makoto Tsunoda On-Chip Liquid Chromatography Encyclopedia micro total analysis system open tubular packed particle monolithic pillar array |
| title | On-Chip Liquid Chromatography |
| title_full | On-Chip Liquid Chromatography |
| title_fullStr | On-Chip Liquid Chromatography |
| title_full_unstemmed | On-Chip Liquid Chromatography |
| title_short | On-Chip Liquid Chromatography |
| title_sort | on chip liquid chromatography |
| topic | micro total analysis system open tubular packed particle monolithic pillar array |
| url | https://www.mdpi.com/2673-8392/2/1/41 |
| work_keys_str_mv | AT makototsunoda onchipliquidchromatography |