Antitumor Immunity and Dietary Compounds
The mechanisms by which natural dietary compounds exert their antitumor effects have been the focus of a large number of research efforts in recent years. Induction of apoptosis by inhibition of cell proliferative pathways is one of the common means of cell death employed by these dietary compounds....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-12-01
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| Series: | Medical Sciences |
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| Online Access: | http://www.mdpi.com/2076-3271/2/1/1 |
| _version_ | 1817990573441679360 |
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| author | Annalise R. Smith Samita Andreansky |
| author_facet | Annalise R. Smith Samita Andreansky |
| author_sort | Annalise R. Smith |
| collection | DOAJ |
| description | The mechanisms by which natural dietary compounds exert their antitumor effects have been the focus of a large number of research efforts in recent years. Induction of apoptosis by inhibition of cell proliferative pathways is one of the common means of cell death employed by these dietary compounds. However, agents that can activate an antitumor immune response in addition to a chemotherapeutic effect may be useful adjuvants or alternative therapies for the treatment of cancer. The focus of this review is to highlight representative dietary compounds, namely Withania somnifera, Panax ginseng, curcumin and resveratrol with special emphasis on their antitumor immune mechanism of action. Each of these dietary compounds and their sources has a history of safe human use as food or in herbal medicine traditions, potentially making them ideal therapeutics. Here we report the recent advances in the cellular immune mechanisms utilized by these compounds to induce antitumor immunity. Taken together, these findings provide a new perspective for exploiting novel dietary compounds as chemoimmunotherapeutic anti-cancer agents. |
| first_indexed | 2024-04-14T01:01:48Z |
| format | Article |
| id | doaj.art-d94b563a2a8b44929a639c8278ce88ad |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-04-14T01:01:48Z |
| publishDate | 2013-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-d94b563a2a8b44929a639c8278ce88ad2022-12-22T02:21:24ZengMDPI AGMedical Sciences2076-32712013-12-012112210.3390/medsci2010001medsci2010001Antitumor Immunity and Dietary CompoundsAnnalise R. Smith0Samita Andreansky1Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USADepartment of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL 33136, USAThe mechanisms by which natural dietary compounds exert their antitumor effects have been the focus of a large number of research efforts in recent years. Induction of apoptosis by inhibition of cell proliferative pathways is one of the common means of cell death employed by these dietary compounds. However, agents that can activate an antitumor immune response in addition to a chemotherapeutic effect may be useful adjuvants or alternative therapies for the treatment of cancer. The focus of this review is to highlight representative dietary compounds, namely Withania somnifera, Panax ginseng, curcumin and resveratrol with special emphasis on their antitumor immune mechanism of action. Each of these dietary compounds and their sources has a history of safe human use as food or in herbal medicine traditions, potentially making them ideal therapeutics. Here we report the recent advances in the cellular immune mechanisms utilized by these compounds to induce antitumor immunity. Taken together, these findings provide a new perspective for exploiting novel dietary compounds as chemoimmunotherapeutic anti-cancer agents.http://www.mdpi.com/2076-3271/2/1/1antitumor immunitynatural productsimmunomodulationcancerWithania somniferaPanax ginsengcurcuminresveratrol |
| spellingShingle | Annalise R. Smith Samita Andreansky Antitumor Immunity and Dietary Compounds Medical Sciences antitumor immunity natural products immunomodulation cancer Withania somnifera Panax ginseng curcumin resveratrol |
| title | Antitumor Immunity and Dietary Compounds |
| title_full | Antitumor Immunity and Dietary Compounds |
| title_fullStr | Antitumor Immunity and Dietary Compounds |
| title_full_unstemmed | Antitumor Immunity and Dietary Compounds |
| title_short | Antitumor Immunity and Dietary Compounds |
| title_sort | antitumor immunity and dietary compounds |
| topic | antitumor immunity natural products immunomodulation cancer Withania somnifera Panax ginseng curcumin resveratrol |
| url | http://www.mdpi.com/2076-3271/2/1/1 |
| work_keys_str_mv | AT annalisersmith antitumorimmunityanddietarycompounds AT samitaandreansky antitumorimmunityanddietarycompounds |