Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities
White matter hyperintensities (WMHs) are commonly observed in older adults and are associated with cognitive impairment. Although previous studies have found abnormal functional connectivities in patients with WMHs based on static functional magnetic resonance imaging (fMRI), the topological propert...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/11/1527 |
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| author | Yuanyuan Liu Shanshan Cao Baogen Du Jun Zhang Chen Chen Panpan Hu Yanghua Tian Kai Wang Gong-Jun Ji Qiang Wei |
| author_facet | Yuanyuan Liu Shanshan Cao Baogen Du Jun Zhang Chen Chen Panpan Hu Yanghua Tian Kai Wang Gong-Jun Ji Qiang Wei |
| author_sort | Yuanyuan Liu |
| collection | DOAJ |
| description | White matter hyperintensities (WMHs) are commonly observed in older adults and are associated with cognitive impairment. Although previous studies have found abnormal functional connectivities in patients with WMHs based on static functional magnetic resonance imaging (fMRI), the topological properties in the context of brain dynamics remain relatively unexplored. Herein, we explored disrupted dynamic topological properties of functional network connectivity in patients with WMHs and its relationship with cognitive impairment. We included 36 healthy controls (HC) and 104 patients with mild WMHs (<i>n</i> = 39), moderate WMHs (<i>n</i> = 37), and severe (<i>n</i> = 28) WMHs. The fMRI data of all participants were analyzed using Anatomical Automatic Labeling (AAL) and a sliding-window approach to generate dynamic functional connectivity matrics. Then, graph theory methods were applied to calculate the topological properties. Comprehensive neuropsychological scales were used to assess cognitive functions. Relationships between cognitive functions and abnormal dynamic topological properties were evaluated by Pearson’s correlation. We found that the patients with WMHs had higher temporal variability in regional properties, including betweenness centrality, nodal efficiencies, and nodal clustering coefficient. Furthermore, we found that the degree of centrality was related to executive function and memory, and the local coefficient correlated to executive function. Our results indicate that patients with WMHs have higher temporal variabilities in regional properties and are associated with executive and memory function. |
| first_indexed | 2024-03-09T18:27:49Z |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T18:27:49Z |
| publishDate | 2022-11-01 |
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| spelling | doaj.art-d94baf58a63747b2a2142165c89b55752023-11-24T07:49:16ZengMDPI AGBrain Sciences2076-34252022-11-011211152710.3390/brainsci12111527Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter HyperintensitiesYuanyuan Liu0Shanshan Cao1Baogen Du2Jun Zhang3Chen Chen4Panpan Hu5Yanghua Tian6Kai Wang7Gong-Jun Ji8Qiang Wei9Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaCollaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei 230032, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaWhite matter hyperintensities (WMHs) are commonly observed in older adults and are associated with cognitive impairment. Although previous studies have found abnormal functional connectivities in patients with WMHs based on static functional magnetic resonance imaging (fMRI), the topological properties in the context of brain dynamics remain relatively unexplored. Herein, we explored disrupted dynamic topological properties of functional network connectivity in patients with WMHs and its relationship with cognitive impairment. We included 36 healthy controls (HC) and 104 patients with mild WMHs (<i>n</i> = 39), moderate WMHs (<i>n</i> = 37), and severe (<i>n</i> = 28) WMHs. The fMRI data of all participants were analyzed using Anatomical Automatic Labeling (AAL) and a sliding-window approach to generate dynamic functional connectivity matrics. Then, graph theory methods were applied to calculate the topological properties. Comprehensive neuropsychological scales were used to assess cognitive functions. Relationships between cognitive functions and abnormal dynamic topological properties were evaluated by Pearson’s correlation. We found that the patients with WMHs had higher temporal variability in regional properties, including betweenness centrality, nodal efficiencies, and nodal clustering coefficient. Furthermore, we found that the degree of centrality was related to executive function and memory, and the local coefficient correlated to executive function. Our results indicate that patients with WMHs have higher temporal variabilities in regional properties and are associated with executive and memory function.https://www.mdpi.com/2076-3425/12/11/1527white matter hyperintensitiescognitive impairmentdynamic topological propertygraph theory |
| spellingShingle | Yuanyuan Liu Shanshan Cao Baogen Du Jun Zhang Chen Chen Panpan Hu Yanghua Tian Kai Wang Gong-Jun Ji Qiang Wei Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities Brain Sciences white matter hyperintensities cognitive impairment dynamic topological property graph theory |
| title | Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities |
| title_full | Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities |
| title_fullStr | Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities |
| title_full_unstemmed | Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities |
| title_short | Different Dynamic Nodal Properties Contribute to Cognitive Impairment in Patients with White Matter Hyperintensities |
| title_sort | different dynamic nodal properties contribute to cognitive impairment in patients with white matter hyperintensities |
| topic | white matter hyperintensities cognitive impairment dynamic topological property graph theory |
| url | https://www.mdpi.com/2076-3425/12/11/1527 |
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