New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System
Acquired immunodeficiency syndrome (AIDS) has become one of the most devastating pandemics in recorded history. The main causal agent of AIDS is the human immunodeficiency virus (HIV), which infects various cell types of the immune system that express the CD4 receptor on their surfaces. Today, combi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/10/1245 |
| _version_ | 1797714122697080832 |
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| author | Victoria Rojas-Celis Fernando Valiente-Echeverría Ricardo Soto-Rifo Daniela Toro-Ascuy |
| author_facet | Victoria Rojas-Celis Fernando Valiente-Echeverría Ricardo Soto-Rifo Daniela Toro-Ascuy |
| author_sort | Victoria Rojas-Celis |
| collection | DOAJ |
| description | Acquired immunodeficiency syndrome (AIDS) has become one of the most devastating pandemics in recorded history. The main causal agent of AIDS is the human immunodeficiency virus (HIV), which infects various cell types of the immune system that express the CD4 receptor on their surfaces. Today, combined antiretroviral therapy (cART) is the standard treatment for all people with HIV; although it has improved the quality of life of people living with HIV (PLWH), it cannot eliminate the latent reservoir of the virus. Therefore HIV/AIDS has turned from a fatal disease to a chronic disease requiring lifelong treatment. Despite significant viral load suppression, it has been observed that at least half of patients under cART present HIV-associated neurocognitive disorders (HAND), which have been related to HIV-1 infection and replication in the central nervous system (CNS). Several studies have focused on elucidating the mechanism by which HIV-1 can invade the CNS and how it can generate the effects seen in HAND. This review summarizes the research on HIV-1 and its interaction with the CNS with an emphasis on the generation of HAND, how the virus enters the CNS, the relationship between HIV-1 and cells of the CNS, and the effect of cART on these cells. |
| first_indexed | 2024-03-12T07:47:16Z |
| format | Article |
| id | doaj.art-d9508e2f8469447bbe8079c4a02f1b1b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:47:16Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d9508e2f8469447bbe8079c4a02f1b1b2023-09-02T20:55:59ZengMDPI AGCells2073-44092019-10-01810124510.3390/cells8101245cells8101245New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous SystemVictoria Rojas-Celis0Fernando Valiente-Echeverría1Ricardo Soto-Rifo2Daniela Toro-Ascuy3Instituto de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago 8910060, ChileMolecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad of Chile, Santiago 8389100, ChileMolecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad of Chile, Santiago 8389100, ChileInstituto de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago 8910060, ChileAcquired immunodeficiency syndrome (AIDS) has become one of the most devastating pandemics in recorded history. The main causal agent of AIDS is the human immunodeficiency virus (HIV), which infects various cell types of the immune system that express the CD4 receptor on their surfaces. Today, combined antiretroviral therapy (cART) is the standard treatment for all people with HIV; although it has improved the quality of life of people living with HIV (PLWH), it cannot eliminate the latent reservoir of the virus. Therefore HIV/AIDS has turned from a fatal disease to a chronic disease requiring lifelong treatment. Despite significant viral load suppression, it has been observed that at least half of patients under cART present HIV-associated neurocognitive disorders (HAND), which have been related to HIV-1 infection and replication in the central nervous system (CNS). Several studies have focused on elucidating the mechanism by which HIV-1 can invade the CNS and how it can generate the effects seen in HAND. This review summarizes the research on HIV-1 and its interaction with the CNS with an emphasis on the generation of HAND, how the virus enters the CNS, the relationship between HIV-1 and cells of the CNS, and the effect of cART on these cells.https://www.mdpi.com/2073-4409/8/10/1245aidshiv-1handcnscartcns cells |
| spellingShingle | Victoria Rojas-Celis Fernando Valiente-Echeverría Ricardo Soto-Rifo Daniela Toro-Ascuy New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System Cells aids hiv-1 hand cns cart cns cells |
| title | New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System |
| title_full | New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System |
| title_fullStr | New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System |
| title_full_unstemmed | New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System |
| title_short | New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System |
| title_sort | new challenges of hiv 1 infection how hiv 1 attacks and resides in the central nervous system |
| topic | aids hiv-1 hand cns cart cns cells |
| url | https://www.mdpi.com/2073-4409/8/10/1245 |
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