Vaccination with chemically attenuated Plasmodium falciparum asexual blood-stage parasites induces parasite-specific cellular immune responses in malaria-naïve volunteers: a pilot study

Vaccination with chemically attenuated Plasmodium falciparum asexual blood-stage parasites induces parasite-specific cellular immune responses in malaria-naïve volunteers: a pilot study

Abstract Background The continuing morbidity and mortality associated with infection with malaria parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in clinical trials in malaria-endemic areas has thus far been disappointing, sparking renewed interest in the...

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Bibliographic Details
Main Authors: Danielle I. Stanisic, James Fink, Johanna Mayer, Sarah Coghill, Letitia Gore, Xue Q. Liu, Ibrahim El-Deeb, Ingrid B. Rodriguez, Jessica Powell, Nicole M. Willemsen, Sai Lata De, Mei-Fong Ho, Stephen L. Hoffman, John Gerrard, Michael F. Good
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Medicine
Subjects:
Malaria
Plasmodium falciparum
Vaccines
Chemically attenuated malaria parasites
T cell responses
Online Access:http://link.springer.com/article/10.1186/s12916-018-1173-9

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