Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections

Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections

ABSTRACTCongenital hearing loss is a common chronic condition affecting children in both developed and developing nations. Viruses correlated with congenital hearing loss include human cytomegalovirus (HCMV) and Zika virus (ZIKV), which causes congenital Zika syndrome. The mechanisms by which HCMV a...

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Bibliographic Details
Main Authors: Alfred T. Harding, Karen Ocwieja, Minjin Jeong, Yichen Zhang, Valerie Leger, Nairuti Jhala, Konstantina M. Stankovic, Lee Gehrke
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
human cytomegalovirus
organoid
inner ear
Zika virus
hearing loss
virus infection
Online Access:https://journals.asm.org/doi/10.1128/mbio.00199-24

Internet

https://journals.asm.org/doi/10.1128/mbio.00199-24

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