Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG Study
BackgroundShort-latency intracortical inhibition (SICI) and motor surround inhibition (mSI) are cortical phenomena that have been investigated with transcranial magnetic stimulation (TMS). mSI is believed to be necessary for the execution of fine finger movements, SICI may participate in mSI genesis...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-06-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00612/full |
| _version_ | 1828520569074614272 |
|---|---|
| author | Giorgio Leodori Nivethida Thirugnanasambandam Hannah Conn Traian Popa Alfredo Berardelli Alfredo Berardelli Mark Hallett |
| author_facet | Giorgio Leodori Nivethida Thirugnanasambandam Hannah Conn Traian Popa Alfredo Berardelli Alfredo Berardelli Mark Hallett |
| author_sort | Giorgio Leodori |
| collection | DOAJ |
| description | BackgroundShort-latency intracortical inhibition (SICI) and motor surround inhibition (mSI) are cortical phenomena that have been investigated with transcranial magnetic stimulation (TMS). mSI is believed to be necessary for the execution of fine finger movements, SICI may participate in mSI genesis, and however, the mechanisms underlying both mSI and SICI are not entirely clear.ObjectiveWe explored the cortical physiology of SICI and mSI in healthy subjects by TMS-evoked cortical potentials (TEPs).Methods:Single (sp) and paired-pulse (pp) TMS were delivered on the ADM muscle cortical hotspot while recording EEG and EMG. Three conditions were tested: spTMS and ppTMS at rest, and spTMS at the onset of an index finger movement. SICI and mSI were calculated on the ADM motor evoked potential (MEP) and two groups were defined based on the presence of mSI. Average TEPs were calculated for each condition and for five regions of interest.ResultsAt movement onset we observed a widespread reduction of the inhibitory late component N100 suggesting cortical facilitation associated with motor performance. At motor cortex level, SICI and mSI are associated with similar modulation of TEPs consisting in a reduction of P30 and an increase of N45 amplitude.ConclusionOur findings suggest that SICI and mSI modulate cortical excitability with shared inhibitory mechanisms. |
| first_indexed | 2024-12-11T19:32:05Z |
| format | Article |
| id | doaj.art-d952f6679b7b4775ae6851e91e69512b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T19:32:05Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-d952f6679b7b4775ae6851e91e69512b2022-12-22T00:53:14ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-06-011310.3389/fnins.2019.00612458087Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG StudyGiorgio Leodori0Nivethida Thirugnanasambandam1Hannah Conn2Traian Popa3Alfredo Berardelli4Alfredo Berardelli5Mark Hallett6IRCCS NEUROMED, Pozzilli, ItalyHuman Motor Control Section, National Institute of Neurological Disorders and Stroke – National Institute of Health, Bethesda, MD, United StatesHuman Motor Control Section, National Institute of Neurological Disorders and Stroke – National Institute of Health, Bethesda, MD, United StatesHuman Motor Control Section, National Institute of Neurological Disorders and Stroke – National Institute of Health, Bethesda, MD, United StatesIRCCS NEUROMED, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyHuman Motor Control Section, National Institute of Neurological Disorders and Stroke – National Institute of Health, Bethesda, MD, United StatesBackgroundShort-latency intracortical inhibition (SICI) and motor surround inhibition (mSI) are cortical phenomena that have been investigated with transcranial magnetic stimulation (TMS). mSI is believed to be necessary for the execution of fine finger movements, SICI may participate in mSI genesis, and however, the mechanisms underlying both mSI and SICI are not entirely clear.ObjectiveWe explored the cortical physiology of SICI and mSI in healthy subjects by TMS-evoked cortical potentials (TEPs).Methods:Single (sp) and paired-pulse (pp) TMS were delivered on the ADM muscle cortical hotspot while recording EEG and EMG. Three conditions were tested: spTMS and ppTMS at rest, and spTMS at the onset of an index finger movement. SICI and mSI were calculated on the ADM motor evoked potential (MEP) and two groups were defined based on the presence of mSI. Average TEPs were calculated for each condition and for five regions of interest.ResultsAt movement onset we observed a widespread reduction of the inhibitory late component N100 suggesting cortical facilitation associated with motor performance. At motor cortex level, SICI and mSI are associated with similar modulation of TEPs consisting in a reduction of P30 and an increase of N45 amplitude.ConclusionOur findings suggest that SICI and mSI modulate cortical excitability with shared inhibitory mechanisms.https://www.frontiersin.org/article/10.3389/fnins.2019.00612/fullelectroencephalographyinhibitionmotor cortexSICITMS-EEGtranscranial magnetic stimulation |
| spellingShingle | Giorgio Leodori Nivethida Thirugnanasambandam Hannah Conn Traian Popa Alfredo Berardelli Alfredo Berardelli Mark Hallett Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG Study Frontiers in Neuroscience electroencephalography inhibition motor cortex SICI TMS-EEG transcranial magnetic stimulation |
| title | Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG Study |
| title_full | Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG Study |
| title_fullStr | Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG Study |
| title_full_unstemmed | Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG Study |
| title_short | Intracortical Inhibition and Surround Inhibition in the Motor Cortex: A TMS-EEG Study |
| title_sort | intracortical inhibition and surround inhibition in the motor cortex a tms eeg study |
| topic | electroencephalography inhibition motor cortex SICI TMS-EEG transcranial magnetic stimulation |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00612/full |
| work_keys_str_mv | AT giorgioleodori intracorticalinhibitionandsurroundinhibitioninthemotorcortexatmseegstudy AT nivethidathirugnanasambandam intracorticalinhibitionandsurroundinhibitioninthemotorcortexatmseegstudy AT hannahconn intracorticalinhibitionandsurroundinhibitioninthemotorcortexatmseegstudy AT traianpopa intracorticalinhibitionandsurroundinhibitioninthemotorcortexatmseegstudy AT alfredoberardelli intracorticalinhibitionandsurroundinhibitioninthemotorcortexatmseegstudy AT alfredoberardelli intracorticalinhibitionandsurroundinhibitioninthemotorcortexatmseegstudy AT markhallett intracorticalinhibitionandsurroundinhibitioninthemotorcortexatmseegstudy |