ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY
Aim: to study the endothelial system in women with undeveloped pregnancy and their fetuses.Materials and methods. The study included 180 first trimester pregnant women. The main group was composed of 90 women, whom a 7-10 week miscarriage was diagnosed followed by an instrumental abortion. The contr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IRBIS LLC
2018-05-01
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| Series: | Акушерство, гинекология и репродукция |
| Subjects: | |
| Online Access: | https://www.gynecology.su/jour/article/view/468 |
| Summary: | Aim: to study the endothelial system in women with undeveloped pregnancy and their fetuses.Materials and methods. The study included 180 first trimester pregnant women. The main group was composed of 90 women, whom a 7-10 week miscarriage was diagnosed followed by an instrumental abortion. The control group included 90 somatic healthy pregnant women, who chose to interrupt their pregnancy by an instrumental abortion. To characterize the endothelium system, we determined the number of desquamated endothelial cells together with cytometric evaluation of cell diameter, perimeter, area, shape, and polarization. Following the instrumental abortion, morphology of the fetal chorion was studied in women of both groups. Light microscopy was used to assess the fetal blood vessels and their differentiation. By means of computed cytomorphometry we determined the primary vessel wall thickness, lumen diameter and its area, as well as the Kernogan index.Results. The cytometric analysis of desquamated endotheliocytes in pregnant women and that of fetal chorion blood vessels showed identical morphological changes in the endothelial systems of all examined women with pathological pregnancy.Conclusion. The endothelial dysfunction found in the first trimester pregnant women is accompanied with changes in the endothelium of the fetal chorion, which can lead to pregnancy failure. |
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| ISSN: | 2313-7347 2500-3194 |