ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY
Aim: to study the endothelial system in women with undeveloped pregnancy and their fetuses.Materials and methods. The study included 180 first trimester pregnant women. The main group was composed of 90 women, whom a 7-10 week miscarriage was diagnosed followed by an instrumental abortion. The contr...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2018-05-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/468 |
| _version_ | 1797884157858152448 |
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| author | A. V. Mironov A. M. Torchinov M. M. Umakhanova O. V. Galachiev |
| author_facet | A. V. Mironov A. M. Torchinov M. M. Umakhanova O. V. Galachiev |
| author_sort | A. V. Mironov |
| collection | DOAJ |
| description | Aim: to study the endothelial system in women with undeveloped pregnancy and their fetuses.Materials and methods. The study included 180 first trimester pregnant women. The main group was composed of 90 women, whom a 7-10 week miscarriage was diagnosed followed by an instrumental abortion. The control group included 90 somatic healthy pregnant women, who chose to interrupt their pregnancy by an instrumental abortion. To characterize the endothelium system, we determined the number of desquamated endothelial cells together with cytometric evaluation of cell diameter, perimeter, area, shape, and polarization. Following the instrumental abortion, morphology of the fetal chorion was studied in women of both groups. Light microscopy was used to assess the fetal blood vessels and their differentiation. By means of computed cytomorphometry we determined the primary vessel wall thickness, lumen diameter and its area, as well as the Kernogan index.Results. The cytometric analysis of desquamated endotheliocytes in pregnant women and that of fetal chorion blood vessels showed identical morphological changes in the endothelial systems of all examined women with pathological pregnancy.Conclusion. The endothelial dysfunction found in the first trimester pregnant women is accompanied with changes in the endothelium of the fetal chorion, which can lead to pregnancy failure. |
| first_indexed | 2024-04-10T04:02:07Z |
| format | Article |
| id | doaj.art-d9561471413d409da0c69aa68b5b5a0a |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:02:07Z |
| publishDate | 2018-05-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-d9561471413d409da0c69aa68b5b5a0a2023-03-13T07:09:49ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942018-05-01121344110.17749/2313-7347.2018.12.1.034-041438ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCYA. V. Mironov0A. M. Torchinov1M. M. Umakhanova2O. V. Galachiev3Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian Federation; City Clinical Hospital № 13, Moscow City Health DepartmentMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian FederationMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian FederationMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian FederationAim: to study the endothelial system in women with undeveloped pregnancy and their fetuses.Materials and methods. The study included 180 first trimester pregnant women. The main group was composed of 90 women, whom a 7-10 week miscarriage was diagnosed followed by an instrumental abortion. The control group included 90 somatic healthy pregnant women, who chose to interrupt their pregnancy by an instrumental abortion. To characterize the endothelium system, we determined the number of desquamated endothelial cells together with cytometric evaluation of cell diameter, perimeter, area, shape, and polarization. Following the instrumental abortion, morphology of the fetal chorion was studied in women of both groups. Light microscopy was used to assess the fetal blood vessels and their differentiation. By means of computed cytomorphometry we determined the primary vessel wall thickness, lumen diameter and its area, as well as the Kernogan index.Results. The cytometric analysis of desquamated endotheliocytes in pregnant women and that of fetal chorion blood vessels showed identical morphological changes in the endothelial systems of all examined women with pathological pregnancy.Conclusion. The endothelial dysfunction found in the first trimester pregnant women is accompanied with changes in the endothelium of the fetal chorion, which can lead to pregnancy failure.https://www.gynecology.su/jour/article/view/468non-developing pregnancycytometry of endotheliocytesendothelial dysfunction |
| spellingShingle | A. V. Mironov A. M. Torchinov M. M. Umakhanova O. V. Galachiev ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY Акушерство, гинекология и репродукция non-developing pregnancy cytometry of endotheliocytes endothelial dysfunction |
| title | ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY |
| title_full | ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY |
| title_fullStr | ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY |
| title_full_unstemmed | ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY |
| title_short | ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY |
| title_sort | endothelial system of mother and fetus during the first trimester of pregnancy |
| topic | non-developing pregnancy cytometry of endotheliocytes endothelial dysfunction |
| url | https://www.gynecology.su/jour/article/view/468 |
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