The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

Summary: The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is required for angiogenesis in health and disease. Here, we position the...

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Bibliographic Details
Main Authors: Josephine Mathilde Elisabeth Tan, Miesje Maxime van der Stoel, Marlene van den Berg, Nienke Marlies van Loon, Martina Moeton, Edwin Scholl, Nicole Neeltje van der Wel, Igor Kovačević, Peter Lodewijk Hordijk, Anke Loregger, Stephan Huveneers, Noam Zelcer
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
VE-cadherin
cholesterol metabolism
endothelial barrier
SQLE
MARCH6
MARCHF6
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309256

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