NODAL inhibition promotes differentiation of pacemaker-like cardiomyocytes from human induced pluripotent stem cells

NODAL inhibition promotes differentiation of pacemaker-like cardiomyocytes from human induced pluripotent stem cells

Directed cardiomyogenesis from human induced pluripotent stem cells (hiPSCs) has been greatly improved in the last decade but directed differentiation to pacemaking cardiomyocytes (CMs) remains incompletely understood. In this study, we demonstrated that inhibition of NODAL signaling by a specific N...

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Bibliographic Details
Main Authors: Sergey Yechikov, Hillary K.J. Kao, Che-Wei Chang, Dalyir Pretto, Xiao-Dong Zhang, Yao-Hui Sun, Regan Smithers, Padmini Sirish, Jan A. Nolta, James W. Chan, Nipavan Chiamvimonvat, Deborah K. Lieu
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Stem Cell Research
Subjects:
Cardiogenesis
Sinoatrial node
Pacemaker
Human induced pluripotent stem cells
Differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120303445

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