Fluorescent diagnostics of non-melanoma skin cancer
Fluorescent diagnostics is a promising method for diagnosing non-melanocytic skin tumors, which makes it possible to identify clinically undetectable skin cancer foci and clarify the margin of the tumor lesion. The main drugs for fluorescent diagnostics are drugs based on 5-aminolevulinic acid and i...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2023-01-01
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| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | https://www.pdt-journal.com/jour/article/view/566 |
| _version_ | 1797883665180524544 |
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| author | E. V. Filonenko V. I. Ivanova-Radkevich |
| author_facet | E. V. Filonenko V. I. Ivanova-Radkevich |
| author_sort | E. V. Filonenko |
| collection | DOAJ |
| description | Fluorescent diagnostics is a promising method for diagnosing non-melanocytic skin tumors, which makes it possible to identify clinically undetectable skin cancer foci and clarify the margin of the tumor lesion. The main drugs for fluorescent diagnostics are drugs based on 5-aminolevulinic acid and its methyl ester. Sensitivity indicators of fluorescent diagnostics in basal cell, squamous cell carcinoma and extramammary Paget’s disease reach 79.0-100.0%, speci city – 55.6-100%. But the effectiveness of this method may be reduced due to hyperkeratinization, keratinization, and the presence of necrotic tissue on the surface of tumor foci. Comparative studies of the results of fluorescent diagnostics and histological mapping during tumor removal using Mohs micrographic surgery showed approximately equal results in the determining of the tumor edges by these methods, which indicates that safe and technically easily performed fluorescent diagnostics can serve as a good alternative to Mohs micrographic surgery, one of the most accurate, but rather labor-intensive and technically complex method for determining the margin of skin cancer foci. |
| first_indexed | 2024-04-10T03:55:27Z |
| format | Article |
| id | doaj.art-d95b4d9a68c645df94c34b4335a7efb6 |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:27Z |
| publishDate | 2023-01-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-d95b4d9a68c645df94c34b4335a7efb62023-03-13T07:12:32ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322023-01-01114324010.24931/2413-9432-2022-11-4-32-40266Fluorescent diagnostics of non-melanoma skin cancerE. V. Filonenko0V. I. Ivanova-Radkevich1«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссийский Университет дружбы народовFluorescent diagnostics is a promising method for diagnosing non-melanocytic skin tumors, which makes it possible to identify clinically undetectable skin cancer foci and clarify the margin of the tumor lesion. The main drugs for fluorescent diagnostics are drugs based on 5-aminolevulinic acid and its methyl ester. Sensitivity indicators of fluorescent diagnostics in basal cell, squamous cell carcinoma and extramammary Paget’s disease reach 79.0-100.0%, speci city – 55.6-100%. But the effectiveness of this method may be reduced due to hyperkeratinization, keratinization, and the presence of necrotic tissue on the surface of tumor foci. Comparative studies of the results of fluorescent diagnostics and histological mapping during tumor removal using Mohs micrographic surgery showed approximately equal results in the determining of the tumor edges by these methods, which indicates that safe and technically easily performed fluorescent diagnostics can serve as a good alternative to Mohs micrographic surgery, one of the most accurate, but rather labor-intensive and technically complex method for determining the margin of skin cancer foci.https://www.pdt-journal.com/jour/article/view/566флуоресцентная диагностикарак кожибазальноклеточный рак кожиплоскоклеточный рак кожиэкстрамаммарный рак педжетакрай опухоли5-аминолевулиновая кислотаметиловый эфир 5-аминолевулиновой кислоты |
| spellingShingle | E. V. Filonenko V. I. Ivanova-Radkevich Fluorescent diagnostics of non-melanoma skin cancer Biomedical Photonics флуоресцентная диагностика рак кожи базальноклеточный рак кожи плоскоклеточный рак кожи экстрамаммарный рак педжета край опухоли 5-аминолевулиновая кислота метиловый эфир 5-аминолевулиновой кислоты |
| title | Fluorescent diagnostics of non-melanoma skin cancer |
| title_full | Fluorescent diagnostics of non-melanoma skin cancer |
| title_fullStr | Fluorescent diagnostics of non-melanoma skin cancer |
| title_full_unstemmed | Fluorescent diagnostics of non-melanoma skin cancer |
| title_short | Fluorescent diagnostics of non-melanoma skin cancer |
| title_sort | fluorescent diagnostics of non melanoma skin cancer |
| topic | флуоресцентная диагностика рак кожи базальноклеточный рак кожи плоскоклеточный рак кожи экстрамаммарный рак педжета край опухоли 5-аминолевулиновая кислота метиловый эфир 5-аминолевулиновой кислоты |
| url | https://www.pdt-journal.com/jour/article/view/566 |
| work_keys_str_mv | AT evfilonenko fluorescentdiagnosticsofnonmelanomaskincancer AT viivanovaradkevich fluorescentdiagnosticsofnonmelanomaskincancer |