Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective Study
Introduction: Complications of COVID-19 infection have been greatly investigated. The most recent studies found strong association of COVID-19 pneumonia with thromboembolism. The aim of research was to describe clinical and computed tomography pulmonary angiograms (CTPA) characteristics of COVID-19...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-05-01
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| Series: | Gerontology and Geriatric Medicine |
| Online Access: | https://doi.org/10.1177/23337214211017398 |
| _version_ | 1818865602041741312 |
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| author | Danijela Budimir Mršić MD, PhD Lara Perković-Tabak MD Marija Ćavar MD, PhD Ante Luetić MD Mate Petričević MD, PhD Krešimir Dolić MD, PhD |
| author_facet | Danijela Budimir Mršić MD, PhD Lara Perković-Tabak MD Marija Ćavar MD, PhD Ante Luetić MD Mate Petričević MD, PhD Krešimir Dolić MD, PhD |
| author_sort | Danijela Budimir Mršić MD, PhD |
| collection | DOAJ |
| description | Introduction: Complications of COVID-19 infection have been greatly investigated. The most recent studies found strong association of COVID-19 pneumonia with thromboembolism. The aim of research was to describe clinical and computed tomography pulmonary angiograms (CTPA) characteristics of COVID-19 related pulmonary artery thromboembolism (PE). Methods: All consecutive CTPA with positive PE in COVID-19 patients from University Hospital Split, from March 23, 2020 to January 31, 2021 were analyzed. Baseline data were collected from patient’s electronic records. CTPA scan analysis identified PE anatomical location (i.e., main, lobar, segmental, or subsegmental). Results: A total number of 78 positive CTPA in COVID-19 patients was mainly in elderly with several co-morbidities, high D-dimer levels, at median of 14 days. CTPAs showed involvement of the entire pulmonary artery tree, mainly of the small-to medium diameter pulmonary artery branches, unilaterally ( n = 31, 39,74%), and bilaterally ( n = 33, 42.31%). The large-diameter branches were the most rarely affected as a single location ( n = 14, 17.95%). Conclusion: PE occurred in predominantly elderly people, having several comorbidities, and high D-dimer levels. Embolic involvement of pulmonary branches of all sizes were found, the most frequent of small to medium diameter branches. Further investigation is needed to better understand mechanisms and course of the COVID-19 related PE. |
| first_indexed | 2024-12-19T10:50:09Z |
| format | Article |
| id | doaj.art-d95b82c3db2640f08b5de421627af38b |
| institution | Directory Open Access Journal |
| issn | 2333-7214 |
| language | English |
| last_indexed | 2024-12-19T10:50:09Z |
| publishDate | 2021-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Gerontology and Geriatric Medicine |
| spelling | doaj.art-d95b82c3db2640f08b5de421627af38b2022-12-21T20:25:03ZengSAGE PublishingGerontology and Geriatric Medicine2333-72142021-05-01710.1177/23337214211017398Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective StudyDanijela Budimir Mršić MD, PhD0Lara Perković-Tabak MD1Marija Ćavar MD, PhD2Ante Luetić MD3Mate Petričević MD, PhD4Krešimir Dolić MD, PhD5University of Split, Split-Dalmatia, CroatiaUniversity Hospital Split, Split-Dalmatia, CroatiaUniversity Hospital Split, Split-Dalmatia, CroatiaUniversity Hospital Split, Split-Dalmatia, CroatiaUniversity Hospital Center Zagreb, CroatiaUniversity of Split, Split-Dalmatia, CroatiaIntroduction: Complications of COVID-19 infection have been greatly investigated. The most recent studies found strong association of COVID-19 pneumonia with thromboembolism. The aim of research was to describe clinical and computed tomography pulmonary angiograms (CTPA) characteristics of COVID-19 related pulmonary artery thromboembolism (PE). Methods: All consecutive CTPA with positive PE in COVID-19 patients from University Hospital Split, from March 23, 2020 to January 31, 2021 were analyzed. Baseline data were collected from patient’s electronic records. CTPA scan analysis identified PE anatomical location (i.e., main, lobar, segmental, or subsegmental). Results: A total number of 78 positive CTPA in COVID-19 patients was mainly in elderly with several co-morbidities, high D-dimer levels, at median of 14 days. CTPAs showed involvement of the entire pulmonary artery tree, mainly of the small-to medium diameter pulmonary artery branches, unilaterally ( n = 31, 39,74%), and bilaterally ( n = 33, 42.31%). The large-diameter branches were the most rarely affected as a single location ( n = 14, 17.95%). Conclusion: PE occurred in predominantly elderly people, having several comorbidities, and high D-dimer levels. Embolic involvement of pulmonary branches of all sizes were found, the most frequent of small to medium diameter branches. Further investigation is needed to better understand mechanisms and course of the COVID-19 related PE.https://doi.org/10.1177/23337214211017398 |
| spellingShingle | Danijela Budimir Mršić MD, PhD Lara Perković-Tabak MD Marija Ćavar MD, PhD Ante Luetić MD Mate Petričević MD, PhD Krešimir Dolić MD, PhD Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective Study Gerontology and Geriatric Medicine |
| title | Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective Study |
| title_full | Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective Study |
| title_fullStr | Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective Study |
| title_full_unstemmed | Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective Study |
| title_short | Pulmonary Embolism Associated with COVID-19 Occurs in Predominantly Elderly Patients with Comorbidities: A Single Center Retrospective Study |
| title_sort | pulmonary embolism associated with covid 19 occurs in predominantly elderly patients with comorbidities a single center retrospective study |
| url | https://doi.org/10.1177/23337214211017398 |
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