The Role of Optical Imaging in Translational Nanomedicine
Nanomedicines have been a major research focus in the past two decades and are increasingly emerging in a broad range of clinical applications. However, a proper understanding of their biodistribution is required to further progress the field of nanomedicine. For this, imaging methods to monitor the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/13/3/137 |
| _version_ | 1797486529964146688 |
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| author | Evelien Hesemans Kiana Buttiens Bella B. Manshian Stefaan J. Soenen |
| author_facet | Evelien Hesemans Kiana Buttiens Bella B. Manshian Stefaan J. Soenen |
| author_sort | Evelien Hesemans |
| collection | DOAJ |
| description | Nanomedicines have been a major research focus in the past two decades and are increasingly emerging in a broad range of clinical applications. However, a proper understanding of their biodistribution is required to further progress the field of nanomedicine. For this, imaging methods to monitor the delivery and therapeutic efficacy of nanoparticles are urgently needed. At present, optical imaging is the most common method used to study the biodistribution of nanomaterials, where the unique properties of nanomaterials and advances in optical imaging can jointly result in novel methods for optimal monitoring of nanomaterials in preclinical animal models. This review article aims to give an introduction to nanomedicines and their translational impact to highlight the potential of optical imaging to study the biodistribution of nanoparticles and to monitor the delivery and therapeutic efficacy at the preclinical level. After introducing both domains, the review focuses on different techniques that can be used to overcome some intrinsic limitations of optical imaging and how this can specifically benefit nanoparticle studies. Finally, we point out some important key features of nanoparticles that currently hinder their full potential in the clinic and how the advances in optical imaging can help to provide us with the information needed to further boost the clinical translation and expand the field of nanomedicines. |
| first_indexed | 2024-03-09T23:34:32Z |
| format | Article |
| id | doaj.art-d95b8ca6d0314d7eb19c5a7b980e27e2 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T23:34:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-d95b8ca6d0314d7eb19c5a7b980e27e22023-11-23T17:03:41ZengMDPI AGJournal of Functional Biomaterials2079-49832022-08-0113313710.3390/jfb13030137The Role of Optical Imaging in Translational NanomedicineEvelien Hesemans0Kiana Buttiens1Bella B. Manshian2Stefaan J. Soenen3NanoHealth and Optical Imaging Group, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, BelgiumNanoHealth and Optical Imaging Group, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, BelgiumTranslational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, BelgiumNanoHealth and Optical Imaging Group, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, BelgiumNanomedicines have been a major research focus in the past two decades and are increasingly emerging in a broad range of clinical applications. However, a proper understanding of their biodistribution is required to further progress the field of nanomedicine. For this, imaging methods to monitor the delivery and therapeutic efficacy of nanoparticles are urgently needed. At present, optical imaging is the most common method used to study the biodistribution of nanomaterials, where the unique properties of nanomaterials and advances in optical imaging can jointly result in novel methods for optimal monitoring of nanomaterials in preclinical animal models. This review article aims to give an introduction to nanomedicines and their translational impact to highlight the potential of optical imaging to study the biodistribution of nanoparticles and to monitor the delivery and therapeutic efficacy at the preclinical level. After introducing both domains, the review focuses on different techniques that can be used to overcome some intrinsic limitations of optical imaging and how this can specifically benefit nanoparticle studies. Finally, we point out some important key features of nanoparticles that currently hinder their full potential in the clinic and how the advances in optical imaging can help to provide us with the information needed to further boost the clinical translation and expand the field of nanomedicines.https://www.mdpi.com/2079-4983/13/3/137optical imagingbioluminescencefluorescencenanomedicinesnanoparticlesbiodistribution |
| spellingShingle | Evelien Hesemans Kiana Buttiens Bella B. Manshian Stefaan J. Soenen The Role of Optical Imaging in Translational Nanomedicine Journal of Functional Biomaterials optical imaging bioluminescence fluorescence nanomedicines nanoparticles biodistribution |
| title | The Role of Optical Imaging in Translational Nanomedicine |
| title_full | The Role of Optical Imaging in Translational Nanomedicine |
| title_fullStr | The Role of Optical Imaging in Translational Nanomedicine |
| title_full_unstemmed | The Role of Optical Imaging in Translational Nanomedicine |
| title_short | The Role of Optical Imaging in Translational Nanomedicine |
| title_sort | role of optical imaging in translational nanomedicine |
| topic | optical imaging bioluminescence fluorescence nanomedicines nanoparticles biodistribution |
| url | https://www.mdpi.com/2079-4983/13/3/137 |
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