Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in Albania
Abstract Introduction Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania. Methods A case–control study was conducted at the Regional Hospital o...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-021-01658-z |
| _version_ | 1819170518388965376 |
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| author | Edite Sadiku Eqerem Hasani Indrit Këlliçi Iris Mone Fatjona Kraja Bledar Kraja Genc Burazeri |
| author_facet | Edite Sadiku Eqerem Hasani Indrit Këlliçi Iris Mone Fatjona Kraja Bledar Kraja Genc Burazeri |
| author_sort | Edite Sadiku |
| collection | DOAJ |
| description | Abstract Introduction Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania. Methods A case–control study was conducted at the Regional Hospital of Durres, the second main district in Albania, a transitional country in South Eastern Europe, including 248 patients with erosive esophagitis (aged 46.5 ± 16.3 years) and 273 controls (aged 46.4 ± 16.0 years; response rate: 70%) enrolled during the period January 2013–June 2014. Both cases and controls underwent upper endoscopy. Information on socio-demographic characteristics and lifestyle factors was also collected. Binary logistic regression was used to assess the association of erosive esophagitis and extra-esophageal symptoms. Results Patients with erosive esophagitis had a higher prevalence of excessive alcohol consumption, smoking, sedentarity, non-Mediterranean diet and obesity compared to their control counterparts (9% vs. 5%, 70% vs. 49%, 31% vs. 17%, 61% vs. 49% and 22% vs. 9%, respectively). Upon adjustment for all socio-demographic characteristics and lifestyle/behavioral factors, there was evidence of a strong association of erosive esophagitis with chronic cough (OR = 3.2, 95% CI = 1.7–5.8), and even more so with laryngeal disorders (OR = 4.4, 95% CI = 2.6–7.5). In all models, the association of erosive esophagitis with any extra-esophageal symptoms was strong and mainly consistent with each of the symptoms separately (fully-adjusted model: OR = 4.6, 95% CI = 2.9–7.3). Conclusion Our findings indicate that the prevalence of extra-esophageal symptoms is higher among patients with erosive esophagitis in a transitional country characterized conventionally by employment of a Mediterranean diet. |
| first_indexed | 2024-12-22T19:36:40Z |
| format | Article |
| id | doaj.art-d95c2f6007a24296adaf761ad1d7abfe |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-22T19:36:40Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-d95c2f6007a24296adaf761ad1d7abfe2022-12-21T18:14:58ZengBMCBMC Gastroenterology1471-230X2021-02-012111810.1186/s12876-021-01658-zExtra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in AlbaniaEdite Sadiku0Eqerem Hasani1Indrit Këlliçi2Iris Mone3Fatjona Kraja4Bledar Kraja5Genc Burazeri6University Clinic of Gastrohepatology and Hepatology Service, University Hospital Center “Mother Teresa”Emergency Departments, University Hospital Center Mother TeresaDivision of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of MedicineDivision of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of MedicineDivision of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of MedicineUniversity Clinic of Gastrohepatology and Hepatology Service, University Hospital Center “Mother Teresa”Department of International Health, School for Public Health and Primary Care (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht UniversityAbstract Introduction Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania. Methods A case–control study was conducted at the Regional Hospital of Durres, the second main district in Albania, a transitional country in South Eastern Europe, including 248 patients with erosive esophagitis (aged 46.5 ± 16.3 years) and 273 controls (aged 46.4 ± 16.0 years; response rate: 70%) enrolled during the period January 2013–June 2014. Both cases and controls underwent upper endoscopy. Information on socio-demographic characteristics and lifestyle factors was also collected. Binary logistic regression was used to assess the association of erosive esophagitis and extra-esophageal symptoms. Results Patients with erosive esophagitis had a higher prevalence of excessive alcohol consumption, smoking, sedentarity, non-Mediterranean diet and obesity compared to their control counterparts (9% vs. 5%, 70% vs. 49%, 31% vs. 17%, 61% vs. 49% and 22% vs. 9%, respectively). Upon adjustment for all socio-demographic characteristics and lifestyle/behavioral factors, there was evidence of a strong association of erosive esophagitis with chronic cough (OR = 3.2, 95% CI = 1.7–5.8), and even more so with laryngeal disorders (OR = 4.4, 95% CI = 2.6–7.5). In all models, the association of erosive esophagitis with any extra-esophageal symptoms was strong and mainly consistent with each of the symptoms separately (fully-adjusted model: OR = 4.6, 95% CI = 2.9–7.3). Conclusion Our findings indicate that the prevalence of extra-esophageal symptoms is higher among patients with erosive esophagitis in a transitional country characterized conventionally by employment of a Mediterranean diet.https://doi.org/10.1186/s12876-021-01658-zAlbaniaErosive reflux esophagitisExtra-esophageal symptomsGERD |
| spellingShingle | Edite Sadiku Eqerem Hasani Indrit Këlliçi Iris Mone Fatjona Kraja Bledar Kraja Genc Burazeri Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in Albania BMC Gastroenterology Albania Erosive reflux esophagitis Extra-esophageal symptoms GERD |
| title | Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in Albania |
| title_full | Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in Albania |
| title_fullStr | Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in Albania |
| title_full_unstemmed | Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in Albania |
| title_short | Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case–control study in Albania |
| title_sort | extra esophageal symptoms in individuals with and without erosive esophagitis a case control study in albania |
| topic | Albania Erosive reflux esophagitis Extra-esophageal symptoms GERD |
| url | https://doi.org/10.1186/s12876-021-01658-z |
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