Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic>
Development and progression of coronary atherosclerotic lesions is mediated by a number of cellular components that are not readily visualized using the current clinical investigation tools. Visualizing these cellular components in situ and in vivo may allow early detection of the vulnerable plaques...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IEEE
2018-01-01
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| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/8502029/ |
| _version_ | 1818927622876299264 |
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| author | Yuemei Luo En Bo Haitao Liang Xianghong Wang Xiaojun Yu Dongyao Cui Xin Ge Jianhua Mo Linbo Liu |
| author_facet | Yuemei Luo En Bo Haitao Liang Xianghong Wang Xiaojun Yu Dongyao Cui Xin Ge Jianhua Mo Linbo Liu |
| author_sort | Yuemei Luo |
| collection | DOAJ |
| description | Development and progression of coronary atherosclerotic lesions is mediated by a number of cellular components that are not readily visualized using the current clinical investigation tools. Visualizing these cellular components in situ and in vivo may allow early detection of the vulnerable plaques, with implications for coronary artery disease therapy and for the prevention of acute myocardial infarction. In this paper, we have developed a fiber-optic micro-optical coherence tomography (μ OCT) probe for intravascular use. We conducted ex vivo imaging experiments in normal swine aorta and human atherosclerotic coronary arteries and demonstrated that the fiber-probe-based μ OCT could delineate not only the layered structures of arterial wall but also the cellular-level anatomical structures of atherosclerotic plaques, including foam cells and smooth muscle cells. These results demonstrate the feasibility of intravascular μ OCT imaging. |
| first_indexed | 2024-12-20T03:15:57Z |
| format | Article |
| id | doaj.art-d95d262582234df18d9137ef194a1e45 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-20T03:15:57Z |
| publishDate | 2018-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-d95d262582234df18d9137ef194a1e452022-12-21T19:55:21ZengIEEEIEEE Access2169-35362018-01-016629886299410.1109/ACCESS.2018.28769198502029Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic>Yuemei Luo0https://orcid.org/0000-0001-8741-449XEn Bo1Haitao Liang2Xianghong Wang3Xiaojun Yu4Dongyao Cui5Xin Ge6Jianhua Mo7Linbo Liu8School of Electrical and Electronic Engineering, Nanyang Technological University, SingaporeSchool of Electrical and Electronic Engineering, Nanyang Technological University, SingaporeSchool of Electrical and Electronic Engineering, Nanyang Technological University, SingaporeSchool of Electrical and Electronic Engineering, Nanyang Technological University, SingaporeSchool of Automation, Northwestern Polytechnical University, Xi’an, ChinaSchool of Electrical and Electronic Engineering, Nanyang Technological University, SingaporeSchool of Electrical and Electronic Engineering, Nanyang Technological University, SingaporeSchool of Electronic and Information Engineering, Soochow University, Suzhou, ChinaSchool of Electrical and Electronic Engineering, Nanyang Technological University, SingaporeDevelopment and progression of coronary atherosclerotic lesions is mediated by a number of cellular components that are not readily visualized using the current clinical investigation tools. Visualizing these cellular components in situ and in vivo may allow early detection of the vulnerable plaques, with implications for coronary artery disease therapy and for the prevention of acute myocardial infarction. In this paper, we have developed a fiber-optic micro-optical coherence tomography (μ OCT) probe for intravascular use. We conducted ex vivo imaging experiments in normal swine aorta and human atherosclerotic coronary arteries and demonstrated that the fiber-probe-based μ OCT could delineate not only the layered structures of arterial wall but also the cellular-level anatomical structures of atherosclerotic plaques, including foam cells and smooth muscle cells. These results demonstrate the feasibility of intravascular μ OCT imaging.https://ieeexplore.ieee.org/document/8502029/Optical fiber devicesoptical coherence tomographyfiber optics imagingintravascular imaging |
| spellingShingle | Yuemei Luo En Bo Haitao Liang Xianghong Wang Xiaojun Yu Dongyao Cui Xin Ge Jianhua Mo Linbo Liu Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic> IEEE Access Optical fiber devices optical coherence tomography fiber optics imaging intravascular imaging |
| title | Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic> |
| title_full | Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic> |
| title_fullStr | Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic> |
| title_full_unstemmed | Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic> |
| title_short | Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe <italic>Ex Vivo</italic> |
| title_sort | imaging cellular structures of atherosclerotic coronary arteries using circumferentially scanning micro optical coherence tomography fiber probe italic ex vivo italic |
| topic | Optical fiber devices optical coherence tomography fiber optics imaging intravascular imaging |
| url | https://ieeexplore.ieee.org/document/8502029/ |
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