| Summary: | Five new perylenequinone derivatives, altertoxins VIII−XII (<b>1</b>−<b>5</b>), as well as one known compound cladosporol I (<b>6</b>), were isolated from the fermentation broth of the marine-derived fungus <i>Cladosporium</i> sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds <b>1</b>−<b>6</b> exhibited quorum sensing inhibitory activities against <i>Chromobacterium violaceum</i> CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.
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