Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33
Five new perylenequinone derivatives, altertoxins VIII−XII (<b>1</b>−<b>5</b>), as well as one known compound cladosporol I (<b>6</b>), were isolated from the fermentation broth of the marine-derived fungus <i>Cladosporium</i> sp. K...
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| Format: | Article |
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MDPI AG
2020-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/1/67 |
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| author | Fei Zhang Liman Zhou Fandong Kong Qingyun Ma Qingyi Xie Jiuhui Li Haofu Dai Lei Guo Youxing Zhao |
| author_facet | Fei Zhang Liman Zhou Fandong Kong Qingyun Ma Qingyi Xie Jiuhui Li Haofu Dai Lei Guo Youxing Zhao |
| author_sort | Fei Zhang |
| collection | DOAJ |
| description | Five new perylenequinone derivatives, altertoxins VIII−XII (<b>1</b>−<b>5</b>), as well as one known compound cladosporol I (<b>6</b>), were isolated from the fermentation broth of the marine-derived fungus <i>Cladosporium</i> sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds <b>1</b>−<b>6</b> exhibited quorum sensing inhibitory activities against <i>Chromobacterium violaceum</i> CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively. |
| first_indexed | 2024-04-11T12:12:17Z |
| format | Article |
| id | doaj.art-d95d32277e8742f7ae465ff172b05801 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:12:17Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-d95d32277e8742f7ae465ff172b058012022-12-22T04:24:36ZengMDPI AGMarine Drugs1660-33972020-01-011816710.3390/md18010067md18010067Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33Fei Zhang0Liman Zhou1Fandong Kong2Qingyun Ma3Qingyi Xie4Jiuhui Li5Haofu Dai6Lei Guo7Youxing Zhao8Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaHainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, ChinaHainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaFive new perylenequinone derivatives, altertoxins VIII−XII (<b>1</b>−<b>5</b>), as well as one known compound cladosporol I (<b>6</b>), were isolated from the fermentation broth of the marine-derived fungus <i>Cladosporium</i> sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds <b>1</b>−<b>6</b> exhibited quorum sensing inhibitory activities against <i>Chromobacterium violaceum</i> CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.https://www.mdpi.com/1660-3397/18/1/67<i>cladosporium</i> sp.altertoxinsquorum sensing inhibitory activity |
| spellingShingle | Fei Zhang Liman Zhou Fandong Kong Qingyun Ma Qingyi Xie Jiuhui Li Haofu Dai Lei Guo Youxing Zhao Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33 Marine Drugs <i>cladosporium</i> sp. altertoxins quorum sensing inhibitory activity |
| title | Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33 |
| title_full | Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33 |
| title_fullStr | Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33 |
| title_full_unstemmed | Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33 |
| title_short | Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33 |
| title_sort | altertoxins with quorum sensing inhibitory activities from the marine derived fungus i cladosporium i sp kfd33 |
| topic | <i>cladosporium</i> sp. altertoxins quorum sensing inhibitory activity |
| url | https://www.mdpi.com/1660-3397/18/1/67 |
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