Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models

Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models

Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer cells. HIF is fundamentally involved in tumor angiogenesis, invasion, and energy metabolism. Inhibition of the transcriptional activity of HI...

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Bibliographic Details
Main Authors: Emily M. Harris, Jonathan D. Strope, Shaunna L. Beedie, Phoebe A. Huang, Andrew K. L. Goey, Kristina M. Cook, Christopher J. Schofield, Cindy H. Chau, Melissa M. Cadelis, Brent R. Copp, Kirk R. Gustafson, William D. Figg
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Marine Drugs
Subjects:
discorhabdins
hypoxia
HIF
angiogenesis
marine natural products
alkaloids
Online Access:http://www.mdpi.com/1660-3397/16/7/241

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