Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic Review
Background: Radiotherapy (RT) plays an important role in the treatment of patients with previously irradiated locally recurrent rectal cancer (LRRC). Over the years, numerous technologies and different types of RT have emerged. The aim of our systematic literature review was to determine whether the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/19/4838 |
| _version_ | 1797576143471116288 |
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| author | Giovanna Mantello Elena Galofaro Silvia Bisello Giuditta Chiloiro Angela Romano Luciana Caravatta Maria Antonietta Gambacorta |
| author_facet | Giovanna Mantello Elena Galofaro Silvia Bisello Giuditta Chiloiro Angela Romano Luciana Caravatta Maria Antonietta Gambacorta |
| author_sort | Giovanna Mantello |
| collection | DOAJ |
| description | Background: Radiotherapy (RT) plays an important role in the treatment of patients with previously irradiated locally recurrent rectal cancer (LRRC). Over the years, numerous technologies and different types of RT have emerged. The aim of our systematic literature review was to determine whether the new techniques have led to improvements in both outcomes and toxicities. Methods: A computerized search was performed by MEDLINE and the Cochrane database. The studies reported data from patients treated with carbon ion radiotherapy (CIRT), intensity-modulated photon radiotherapy (IMRT), and stereotactic radiotherapy (SBRT). Results: Seven publications of the 126 titles/abstracts that emerged from our search met the inclusion criteria and presented outcomes of 230 patients. OS was reported with rates of 90.0% and 73.0% at 1 and 2 years, respectively; LC was 89.0% and 71.6% at 1 and 2 years after re-RT, respectively. Toxicity data vary widely, with emphasis on acute and chronic gastrointestinal and urogenital toxicity, even with modern techniques. Conclusion: data on toxicity and outcomes of re-RT for LRRC with new technologies are promising compared with 3D techniques. Comparative studies are needed to define the best technique, also in relation to the site of recurrence. |
| first_indexed | 2024-03-10T21:48:04Z |
| format | Article |
| id | doaj.art-d95fb5443bda41cf861a22bb4679dc83 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T21:48:04Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d95fb5443bda41cf861a22bb4679dc832023-11-19T14:11:18ZengMDPI AGCancers2072-66942023-10-011519483810.3390/cancers15194838Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic ReviewGiovanna Mantello0Elena Galofaro1Silvia Bisello2Giuditta Chiloiro3Angela Romano4Luciana Caravatta5Maria Antonietta Gambacorta6Radiotherapy Department, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, ItalyRadiotherapy Department, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, ItalyRadiotherapy Department, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, ItalyDepartments of Radiation Oncology, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Roma, ItalyDepartments of Radiation Oncology, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Roma, ItalyDepartment of Radiation Oncology, SS Annunziata Hospital, 66100 Chieti, ItalyDepartments of Radiation Oncology, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Roma, ItalyBackground: Radiotherapy (RT) plays an important role in the treatment of patients with previously irradiated locally recurrent rectal cancer (LRRC). Over the years, numerous technologies and different types of RT have emerged. The aim of our systematic literature review was to determine whether the new techniques have led to improvements in both outcomes and toxicities. Methods: A computerized search was performed by MEDLINE and the Cochrane database. The studies reported data from patients treated with carbon ion radiotherapy (CIRT), intensity-modulated photon radiotherapy (IMRT), and stereotactic radiotherapy (SBRT). Results: Seven publications of the 126 titles/abstracts that emerged from our search met the inclusion criteria and presented outcomes of 230 patients. OS was reported with rates of 90.0% and 73.0% at 1 and 2 years, respectively; LC was 89.0% and 71.6% at 1 and 2 years after re-RT, respectively. Toxicity data vary widely, with emphasis on acute and chronic gastrointestinal and urogenital toxicity, even with modern techniques. Conclusion: data on toxicity and outcomes of re-RT for LRRC with new technologies are promising compared with 3D techniques. Comparative studies are needed to define the best technique, also in relation to the site of recurrence.https://www.mdpi.com/2072-6694/15/19/4838recurrencerectal cancerre-irradiationradiotherapyreview |
| spellingShingle | Giovanna Mantello Elena Galofaro Silvia Bisello Giuditta Chiloiro Angela Romano Luciana Caravatta Maria Antonietta Gambacorta Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic Review Cancers recurrence rectal cancer re-irradiation radiotherapy review |
| title | Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic Review |
| title_full | Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic Review |
| title_fullStr | Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic Review |
| title_full_unstemmed | Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic Review |
| title_short | Modern Techniques in Re-Irradiation for Locally Recurrent Rectal Cancer: A Systematic Review |
| title_sort | modern techniques in re irradiation for locally recurrent rectal cancer a systematic review |
| topic | recurrence rectal cancer re-irradiation radiotherapy review |
| url | https://www.mdpi.com/2072-6694/15/19/4838 |
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