Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease
Background & objectives: Cardiovascular disease (CVD) remains the leading cause of mortality among patients with chronic kidney disease (CKD). Liver function tests (LFTs) have emerged as markers of CVD risk in some population-based studies. Hence, in the present study the relation between LFTs a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2022;volume=155;issue=3;spage=397;epage=402;aulast=Selen |
| _version_ | 1797995753275129856 |
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| author | Tamer Selen Hadim Akoglu Kemal Agbaht |
| author_facet | Tamer Selen Hadim Akoglu Kemal Agbaht |
| author_sort | Tamer Selen |
| collection | DOAJ |
| description | Background & objectives: Cardiovascular disease (CVD) remains the leading cause of mortality among patients with chronic kidney disease (CKD). Liver function tests (LFTs) have emerged as markers of CVD risk in some population-based studies. Hence, in the present study the relation between LFTs and biochemical cardiovascular risk factors (CRFs) were evaluated in CKD patients.
Methods: A total of 246 patients with stage 3-5 pre-dialysis CKD were enrolled. Demographics, LFTs [alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT)] and biochemical CRFs were recorded retrospectively. Glomerular filtration rate (GFR) was calculated using CKD-EPI equation.
Results: ALT was positively correlated with GFR, albumin, triglyceride and 25-hydroxyvitamin D and negatively correlated with CRP and intact parathyroid hormone (iPTH); AST was positively correlated with GFR, albumin, high-density lipoprotein cholesterol (HDL-C) and 25-hydroxyvitamin D and negatively correlated with CRP and iPTH; GGT was positively correlated with GFR, CRP and triglyceride and negatively correlated with HDL-C. In diabetic patients, ALT correlated positively with GFR; AST correlated positively with GFR and HDL-C, but correlated negatively with iPTH. In the correlation analysis between GFR and CRF, GFR was positively correlated with albumin, triglyceride and 25-hydroxyvitamin D and negatively correlated with CRP, iPTH and albuminuria in both total study population and diabetic group. A partial correlation analysis revealed no correlation between LFTs and CRFs after being controlled for GFR.
Interpretation & conclusions: The results of the present study suggest that the relationship between LFTs and biochemical CRFs seems to be a function of impaired GFR. |
| first_indexed | 2024-04-11T10:06:42Z |
| format | Article |
| id | doaj.art-d96084b62bf041f3970e6a146817f933 |
| institution | Directory Open Access Journal |
| issn | 0971-5916 |
| language | English |
| last_indexed | 2024-04-11T10:06:42Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Research |
| spelling | doaj.art-d96084b62bf041f3970e6a146817f9332022-12-22T04:30:14ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Research0971-59162022-01-01155339740210.4103/ijmr.IJMR_1777_19Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney diseaseTamer SelenHadim AkogluKemal AgbahtBackground & objectives: Cardiovascular disease (CVD) remains the leading cause of mortality among patients with chronic kidney disease (CKD). Liver function tests (LFTs) have emerged as markers of CVD risk in some population-based studies. Hence, in the present study the relation between LFTs and biochemical cardiovascular risk factors (CRFs) were evaluated in CKD patients. Methods: A total of 246 patients with stage 3-5 pre-dialysis CKD were enrolled. Demographics, LFTs [alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT)] and biochemical CRFs were recorded retrospectively. Glomerular filtration rate (GFR) was calculated using CKD-EPI equation. Results: ALT was positively correlated with GFR, albumin, triglyceride and 25-hydroxyvitamin D and negatively correlated with CRP and intact parathyroid hormone (iPTH); AST was positively correlated with GFR, albumin, high-density lipoprotein cholesterol (HDL-C) and 25-hydroxyvitamin D and negatively correlated with CRP and iPTH; GGT was positively correlated with GFR, CRP and triglyceride and negatively correlated with HDL-C. In diabetic patients, ALT correlated positively with GFR; AST correlated positively with GFR and HDL-C, but correlated negatively with iPTH. In the correlation analysis between GFR and CRF, GFR was positively correlated with albumin, triglyceride and 25-hydroxyvitamin D and negatively correlated with CRP, iPTH and albuminuria in both total study population and diabetic group. A partial correlation analysis revealed no correlation between LFTs and CRFs after being controlled for GFR. Interpretation & conclusions: The results of the present study suggest that the relationship between LFTs and biochemical CRFs seems to be a function of impaired GFR.http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2022;volume=155;issue=3;spage=397;epage=402;aulast=Selenalanine aminotransferase - aspartate aminotransferase - cardiovascular disease - gamma-glutamyltransferase - kidney disease - risk factors |
| spellingShingle | Tamer Selen Hadim Akoglu Kemal Agbaht Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease Indian Journal of Medical Research alanine aminotransferase - aspartate aminotransferase - cardiovascular disease - gamma-glutamyltransferase - kidney disease - risk factors |
| title | Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease |
| title_full | Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease |
| title_fullStr | Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease |
| title_full_unstemmed | Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease |
| title_short | Relationship between liver function tests & cardiovascular risk factors in stage 3-5 pre-dialysis chronic kidney disease |
| title_sort | relationship between liver function tests cardiovascular risk factors in stage 3 5 pre dialysis chronic kidney disease |
| topic | alanine aminotransferase - aspartate aminotransferase - cardiovascular disease - gamma-glutamyltransferase - kidney disease - risk factors |
| url | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2022;volume=155;issue=3;spage=397;epage=402;aulast=Selen |
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