Integrative epigenome profiling of 47XXY provides insights into whole genomic DNA hypermethylation and active chromatin accessibility

Integrative epigenome profiling of 47XXY provides insights into whole genomic DNA hypermethylation and active chromatin accessibility

Klinefelter syndrome (KS, 47XXY) is a disorder characterized by sex chromosomal aneuploidy, which may lead to changes in epigenetic regulations of gene expression. To define epigenetic architectures in 47XXY, we annotated DNA methylation in euploid males (46XY) and females (46XX), and 47XXY individu...

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Bibliographic Details
Main Authors: Nan Miao, Zhiwei Zeng, Trevor Lee, Qiwei Guo, Wenwei Zheng, Wenjie Cai, Wanhua Chen, Jing Wang, Tao Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
klinefelter syndrome
DNA methylation
chromosomal accessibility
ATAC-seq
epigenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1128739/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1128739/full

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