Vitamin D and K Supplementation Is Associated with Changes in the Methylation Profile of U266-Multiple Myeloma Cells, Influencing the Proliferative Potential and Resistance to Bortezomib

Vitamin D and K Supplementation Is Associated with Changes in the Methylation Profile of U266-Multiple Myeloma Cells, Influencing the Proliferative Potential and Resistance to Bortezomib

Multiple myeloma (MM) is a plasma cell malignancy that, despite recent advances in therapy, continues to pose a major challenge to hematologists. Currently, different classes of drugs are applied to treat MM, among others, proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. Mos...

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Bibliographic Details
Main Authors: Karolina Łuczkowska, Piotr Kulig, Bartłomiej Baumert, Bogusław Machaliński
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Nutrients
Subjects:
multiple myeloma
vitamin D
bortezomib
drug resistance
Online Access:https://www.mdpi.com/2072-6643/16/1/142

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