Expression profiling of host long non-coding RNAs under ORF virus infection
The present study aimed at gaining insights into the expression profile of long non-coding RNAs (lncRNAs) and coding genes of Orf virus (ORFV) infected oral mucosal tissues of sheep using RNA-Seq technology. Specifically, an expression profile and lncRNA-mRNA interaction network was inferred from a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indian Council of Agricultural Research
2020-07-01
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| Series: | Indian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | https://epubs.icar.org.in/index.php/IJAnS/article/view/102319 |
| _version_ | 1797896773037981696 |
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| author | ARUNA PANDEY SHIKHA SAXENA RAJA ISHAQNABI KHAN RAVI KUMAR GANDHAM PRAMOD W RAMTEKE |
| author_facet | ARUNA PANDEY SHIKHA SAXENA RAJA ISHAQNABI KHAN RAVI KUMAR GANDHAM PRAMOD W RAMTEKE |
| author_sort | ARUNA PANDEY |
| collection | DOAJ |
| description | The present study aimed at gaining insights into the expression profile of long non-coding RNAs (lncRNAs) and coding genes of Orf virus (ORFV) infected oral mucosal tissues of sheep using RNA-Seq technology. Specifically, an expression profile and lncRNA-mRNA interaction network was inferred from a large-scale gene expression data set of sheep mucosal tissues on 0, 3, 7 and 15 days after ORFV infection. RNA-Seq profiles were obtained from the Gene Expression Omnibus (GEO) database. We found that 45, 64 and 45 lncRNAs and 1796, 2182 and 1550 coding genes were differentially expressed at early (T3), intermediate (T7) and late (T15) stages of ORFV infection in sheep mucosal tissues, respectively. Functional analysis revealed that differentially expressed long non-coding RNAs (DElncRNAs) regulate immune processes by regulating the expression level of differentially expressed coding genes (DEGs) under ORFV infection. |
| first_indexed | 2024-04-10T07:48:07Z |
| format | Article |
| id | doaj.art-d961bd282a28435dac35334edd387a50 |
| institution | Directory Open Access Journal |
| issn | 0367-8318 2394-3327 |
| language | English |
| last_indexed | 2024-04-10T07:48:07Z |
| publishDate | 2020-07-01 |
| publisher | Indian Council of Agricultural Research |
| record_format | Article |
| series | Indian Journal of Animal Sciences |
| spelling | doaj.art-d961bd282a28435dac35334edd387a502023-02-23T10:27:41ZengIndian Council of Agricultural ResearchIndian Journal of Animal Sciences0367-83182394-33272020-07-0190310.56093/ijans.v90i3.102319Expression profiling of host long non-coding RNAs under ORF virus infectionARUNA PANDEY0SHIKHA SAXENA1RAJA ISHAQNABI KHAN2RAVI KUMAR GANDHAM3PRAMOD W RAMTEKE4ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 IndiaICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 IndiaICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 IndiaICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 IndiaICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 IndiaThe present study aimed at gaining insights into the expression profile of long non-coding RNAs (lncRNAs) and coding genes of Orf virus (ORFV) infected oral mucosal tissues of sheep using RNA-Seq technology. Specifically, an expression profile and lncRNA-mRNA interaction network was inferred from a large-scale gene expression data set of sheep mucosal tissues on 0, 3, 7 and 15 days after ORFV infection. RNA-Seq profiles were obtained from the Gene Expression Omnibus (GEO) database. We found that 45, 64 and 45 lncRNAs and 1796, 2182 and 1550 coding genes were differentially expressed at early (T3), intermediate (T7) and late (T15) stages of ORFV infection in sheep mucosal tissues, respectively. Functional analysis revealed that differentially expressed long non-coding RNAs (DElncRNAs) regulate immune processes by regulating the expression level of differentially expressed coding genes (DEGs) under ORFV infection.https://epubs.icar.org.in/index.php/IJAnS/article/view/102319ApoptosislncRNAsORFVRNA-SeqSheep |
| spellingShingle | ARUNA PANDEY SHIKHA SAXENA RAJA ISHAQNABI KHAN RAVI KUMAR GANDHAM PRAMOD W RAMTEKE Expression profiling of host long non-coding RNAs under ORF virus infection Indian Journal of Animal Sciences Apoptosis lncRNAs ORFV RNA-Seq Sheep |
| title | Expression profiling of host long non-coding RNAs under ORF virus infection |
| title_full | Expression profiling of host long non-coding RNAs under ORF virus infection |
| title_fullStr | Expression profiling of host long non-coding RNAs under ORF virus infection |
| title_full_unstemmed | Expression profiling of host long non-coding RNAs under ORF virus infection |
| title_short | Expression profiling of host long non-coding RNAs under ORF virus infection |
| title_sort | expression profiling of host long non coding rnas under orf virus infection |
| topic | Apoptosis lncRNAs ORFV RNA-Seq Sheep |
| url | https://epubs.icar.org.in/index.php/IJAnS/article/view/102319 |
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