Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy
Objectives: The brain atrophy commonly occurs in elderly and in some childhood conditions making the techniques for quantifying brain volume needful. Since the automated quantitative methods of brain volume assessment have limited availability in developing countries, it was the purpose of this stud...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | European Journal of Radiology Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047720300708 |
| _version_ | 1819078220253757440 |
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| author | R Sungura E Mpolya JM Spitsbergen C Onyambu E Sauli J-M Vianney |
| author_facet | R Sungura E Mpolya JM Spitsbergen C Onyambu E Sauli J-M Vianney |
| author_sort | R Sungura |
| collection | DOAJ |
| description | Objectives: The brain atrophy commonly occurs in elderly and in some childhood conditions making the techniques for quantifying brain volume needful. Since the automated quantitative methods of brain volume assessment have limited availability in developing countries, it was the purpose of this study to design and test an alternative formula that is applicable to all healthcare levels. Methods: The multi-linear diagonal brain fraction formula (DBF) was designed from dimensions of brain relative to skull and ventricles. To test a developed formula, a total of 347 subjects aged between 0 and 18 years who had brain CT scans performed recruited and subjected to a systematic measurement of their brains in a diagonal brain fashion. Results: Out of 347 patients evaluated, 62 subjects (17.8 %) were found to be cases of brain atrophy. The three radiological measurements which included sulcal width (SW), ventricular width (VW) and Evans Index (EI) were concurrently performed. SW and VW showed good age correlation. Similar tests were extended to diagonal brain fraction (DBF) and skull vertical horizontal ratio (VHR) in which DBF showed significant age correlation. Conclusions: The DBF formula shows significant ability of differentiating changes of brain volume suggesting that it can be utilized as an alternative brain fraction quantification method bearing technical simplicity in assessing gross brain volume. Advances in knowledge: The designed formula is unique in that it captures even the possible asymmetrical volume loss of brain through diagonal lines. The proposed scores being in term of ratios give four grades of brain atrophy. |
| first_indexed | 2024-12-21T19:09:38Z |
| format | Article |
| id | doaj.art-d961d0ae328b496e8f12b898ba6d3420 |
| institution | Directory Open Access Journal |
| issn | 2352-0477 |
| language | English |
| last_indexed | 2024-12-21T19:09:38Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Radiology Open |
| spelling | doaj.art-d961d0ae328b496e8f12b898ba6d34202022-12-21T18:53:14ZengElsevierEuropean Journal of Radiology Open2352-04772020-01-017100281Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophyR Sungura0E Mpolya1JM Spitsbergen2C Onyambu3E Sauli4J-M Vianney5Department of Health and Biomedical Sciences, School of Life Science and Bioengineering, Nelson Mandela-African Institution of Science and Technology, Arusha, Tanzania; Corresponding author at: Mount Meru Regional Referral Hospital, Arusha, Tanzania.Department of Health and Biomedical Sciences, School of Life Science and Bioengineering, Nelson Mandela-African Institution of Science and Technology, Arusha, TanzaniaDepartment of Biological Sciences, Western Michigan University, USADepartment of Diagnostic and Radiation Medicine, School of Health Sciences, University of Nairobi, KenyaDepartment of Health and Biomedical Sciences, School of Life Science and Bioengineering, Nelson Mandela-African Institution of Science and Technology, Arusha, TanzaniaDepartment of Health and Biomedical Sciences, School of Life Science and Bioengineering, Nelson Mandela-African Institution of Science and Technology, Arusha, TanzaniaObjectives: The brain atrophy commonly occurs in elderly and in some childhood conditions making the techniques for quantifying brain volume needful. Since the automated quantitative methods of brain volume assessment have limited availability in developing countries, it was the purpose of this study to design and test an alternative formula that is applicable to all healthcare levels. Methods: The multi-linear diagonal brain fraction formula (DBF) was designed from dimensions of brain relative to skull and ventricles. To test a developed formula, a total of 347 subjects aged between 0 and 18 years who had brain CT scans performed recruited and subjected to a systematic measurement of their brains in a diagonal brain fashion. Results: Out of 347 patients evaluated, 62 subjects (17.8 %) were found to be cases of brain atrophy. The three radiological measurements which included sulcal width (SW), ventricular width (VW) and Evans Index (EI) were concurrently performed. SW and VW showed good age correlation. Similar tests were extended to diagonal brain fraction (DBF) and skull vertical horizontal ratio (VHR) in which DBF showed significant age correlation. Conclusions: The DBF formula shows significant ability of differentiating changes of brain volume suggesting that it can be utilized as an alternative brain fraction quantification method bearing technical simplicity in assessing gross brain volume. Advances in knowledge: The designed formula is unique in that it captures even the possible asymmetrical volume loss of brain through diagonal lines. The proposed scores being in term of ratios give four grades of brain atrophy.http://www.sciencedirect.com/science/article/pii/S2352047720300708Brain atrophyBrain volumeNeuroimagingQuantification |
| spellingShingle | R Sungura E Mpolya JM Spitsbergen C Onyambu E Sauli J-M Vianney Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy European Journal of Radiology Open Brain atrophy Brain volume Neuroimaging Quantification |
| title | Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy |
| title_full | Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy |
| title_fullStr | Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy |
| title_full_unstemmed | Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy |
| title_short | Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy |
| title_sort | novel multi linear quantitative brain volume formula for manual radiological evaluation of brain atrophy |
| topic | Brain atrophy Brain volume Neuroimaging Quantification |
| url | http://www.sciencedirect.com/science/article/pii/S2352047720300708 |
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