Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins
A series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. The structures of the newly-synthesized compounds were characterized by spectral and elememental analysis or HRMS measurements. Their antioxidant properties wer...
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| Format: | Article |
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MDPI AG
2016-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/2/138 |
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| author | Antigoni Kotali Despina A. Nasiopoulou Constantinos A. Tsoleridis Philip A. Harris Christos A. Kontogiorgis Dimitra J. Hadjipavlou-Litina |
| author_facet | Antigoni Kotali Despina A. Nasiopoulou Constantinos A. Tsoleridis Philip A. Harris Christos A. Kontogiorgis Dimitra J. Hadjipavlou-Litina |
| author_sort | Antigoni Kotali |
| collection | DOAJ |
| description | A series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. The structures of the newly-synthesized compounds were characterized by spectral and elememental analysis or HRMS measurements. Their antioxidant properties were evaluated by using scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as well as inhibition of lipid peroxidation. Moreover, their ability to inhibit in vitro soybean lipoxygenase has been investigated. They were found to be capable of rapid inactivation of alkylperoxy radicals. |
| first_indexed | 2024-12-11T10:49:35Z |
| format | Article |
| id | doaj.art-d962c852553946439b8ea2ad67162ac4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T10:49:35Z |
| publishDate | 2016-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d962c852553946439b8ea2ad67162ac42022-12-22T01:10:22ZengMDPI AGMolecules1420-30492016-01-0121213810.3390/molecules21020138molecules21020138Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarinsAntigoni Kotali0Despina A. Nasiopoulou1Constantinos A. Tsoleridis2Philip A. Harris3Christos A. Kontogiorgis4Dimitra J. Hadjipavlou-Litina5Laboratory of Organic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, GreeceLaboratory of Organic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, GreeceLaboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, GreeceGlaxoSmithKline, 1250 South Collegeville Road, P. O. Box 5089, Collegeville, PA 19426-0989, USADepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, GreeceDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, GreeceA series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. The structures of the newly-synthesized compounds were characterized by spectral and elememental analysis or HRMS measurements. Their antioxidant properties were evaluated by using scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as well as inhibition of lipid peroxidation. Moreover, their ability to inhibit in vitro soybean lipoxygenase has been investigated. They were found to be capable of rapid inactivation of alkylperoxy radicals.http://www.mdpi.com/1420-3049/21/2/138antioxidants3-acetyl-4-hydroxycoumarinacyl hydrazonesDPPHtroloxlipid peroxidationsoybean lipoxygenase |
| spellingShingle | Antigoni Kotali Despina A. Nasiopoulou Constantinos A. Tsoleridis Philip A. Harris Christos A. Kontogiorgis Dimitra J. Hadjipavlou-Litina Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins Molecules antioxidants 3-acetyl-4-hydroxycoumarin acyl hydrazones DPPH trolox lipid peroxidation soybean lipoxygenase |
| title | Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins |
| title_full | Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins |
| title_fullStr | Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins |
| title_full_unstemmed | Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins |
| title_short | Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins |
| title_sort | antioxidant activity of 3 n acylhydrazono ethyl 4 hydroxy coumarins |
| topic | antioxidants 3-acetyl-4-hydroxycoumarin acyl hydrazones DPPH trolox lipid peroxidation soybean lipoxygenase |
| url | http://www.mdpi.com/1420-3049/21/2/138 |
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