Computational surprisal analysis speeds-up genomic characterization of cancer processes.
Surprisal analysis is increasingly being applied for the examination of transcription levels in cellular processes, towards revealing inner network structures and predicting response. But to achieve its full potential, surprisal analysis should be integrated into a wider range computational tool. Th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4236016?pdf=render |
| _version_ | 1811261767596113920 |
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| author | Nataly Kravchenko-Balasha Simcha Simon R D Levine F Remacle Iaakov Exman |
| author_facet | Nataly Kravchenko-Balasha Simcha Simon R D Levine F Remacle Iaakov Exman |
| author_sort | Nataly Kravchenko-Balasha |
| collection | DOAJ |
| description | Surprisal analysis is increasingly being applied for the examination of transcription levels in cellular processes, towards revealing inner network structures and predicting response. But to achieve its full potential, surprisal analysis should be integrated into a wider range computational tool. The purposes of this paper are to combine surprisal analysis with other important computation procedures, such as easy manipulation of the analysis results--e.g. to choose desirable result sub-sets for further inspection--, retrieval and comparison with relevant datasets from public databases, and flexible graphical displays for heuristic thinking. The whole set of computation procedures integrated into a single practical tool is what we call Computational Surprisal Analysis. This combined kind of analysis should facilitate significantly quantitative understanding of different cellular processes for researchers, including applications in proteomics and metabolomics. Beyond that, our vision is that Computational Surprisal Analysis has the potential to reach the status of a routine method of analysis for practitioners. The resolving power of Computational Surprisal Analysis is here demonstrated by its application to a variety of cellular cancer process transcription datasets, ours and from the literature. The results provide a compact biological picture of the thermodynamic significance of the leading gene expression phenotypes in every stage of the disease. For each transcript we characterize both its inherent steady state weight, its correlation with the other transcripts and its variation due to the disease. We present a dedicated website to facilitate the analysis for researchers and practitioners. |
| first_indexed | 2024-04-12T19:11:46Z |
| format | Article |
| id | doaj.art-d9644efb33f440a5ac3f419a470eb7d8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T19:11:46Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d9644efb33f440a5ac3f419a470eb7d82022-12-22T03:19:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e10854910.1371/journal.pone.0108549Computational surprisal analysis speeds-up genomic characterization of cancer processes.Nataly Kravchenko-BalashaSimcha SimonR D LevineF RemacleIaakov ExmanSurprisal analysis is increasingly being applied for the examination of transcription levels in cellular processes, towards revealing inner network structures and predicting response. But to achieve its full potential, surprisal analysis should be integrated into a wider range computational tool. The purposes of this paper are to combine surprisal analysis with other important computation procedures, such as easy manipulation of the analysis results--e.g. to choose desirable result sub-sets for further inspection--, retrieval and comparison with relevant datasets from public databases, and flexible graphical displays for heuristic thinking. The whole set of computation procedures integrated into a single practical tool is what we call Computational Surprisal Analysis. This combined kind of analysis should facilitate significantly quantitative understanding of different cellular processes for researchers, including applications in proteomics and metabolomics. Beyond that, our vision is that Computational Surprisal Analysis has the potential to reach the status of a routine method of analysis for practitioners. The resolving power of Computational Surprisal Analysis is here demonstrated by its application to a variety of cellular cancer process transcription datasets, ours and from the literature. The results provide a compact biological picture of the thermodynamic significance of the leading gene expression phenotypes in every stage of the disease. For each transcript we characterize both its inherent steady state weight, its correlation with the other transcripts and its variation due to the disease. We present a dedicated website to facilitate the analysis for researchers and practitioners.http://europepmc.org/articles/PMC4236016?pdf=render |
| spellingShingle | Nataly Kravchenko-Balasha Simcha Simon R D Levine F Remacle Iaakov Exman Computational surprisal analysis speeds-up genomic characterization of cancer processes. PLoS ONE |
| title | Computational surprisal analysis speeds-up genomic characterization of cancer processes. |
| title_full | Computational surprisal analysis speeds-up genomic characterization of cancer processes. |
| title_fullStr | Computational surprisal analysis speeds-up genomic characterization of cancer processes. |
| title_full_unstemmed | Computational surprisal analysis speeds-up genomic characterization of cancer processes. |
| title_short | Computational surprisal analysis speeds-up genomic characterization of cancer processes. |
| title_sort | computational surprisal analysis speeds up genomic characterization of cancer processes |
| url | http://europepmc.org/articles/PMC4236016?pdf=render |
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