EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS
The aim of this work is to investigate the level of mononuclear cells, expressing intercellular adhesion molecule (CD54+), pro- (IL-1, TNF-a) and antiinflammatory (IL-4, TGF-в) blood cytokines in the patients with pyelonephritis PN, to determine the peculiarities in acute and chronic its course....
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| Format: | Article |
| Language: | English |
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State Institution «Institute of Nephrology NAMS of Ukraine"
2015-01-01
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| Series: | Український Журнал Нефрології та Діалізу |
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| Online Access: | https://ukrjnd.com.ua/index.php/journal/article/view/89 |
| _version_ | 1797261467367505920 |
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| author | F.Z. Gaysenyuk |
| author_facet | F.Z. Gaysenyuk |
| author_sort | F.Z. Gaysenyuk |
| collection | DOAJ |
| description |
The aim of this work is to investigate the level of mononuclear cells, expressing intercellular adhesion molecule (CD54+), pro- (IL-1, TNF-a) and antiinflammatory (IL-4, TGF-в) blood cytokines in the patients with pyelonephritis PN, to determine the peculiarities in acute and chronic its course.
Materials and methods. The immuno-enzymic method ELISA and the corresponding test-systems (“Diaclone”, “DRG”) were used to study the levels of blood cytokines and immuno-fluorescent with “Coltage” (USA) – the level of CD54+-cells.
Results. It has been demonstrated that CD54+-lymphocytes, IL-1, TNF-a, IL-4 and TGF-ft in blood were increased in patients with acute and chronic pyelonephritis, compared with healthies. The number of lymphocytes expressing CD54 and the level of TGF-ft were higher in patients with chronic pyelonephritis.
Conclusion. The high level of cytokines and CD54+-lymphocytes in blood ofpatients confirm their important role in immunogenesis of pyelonephritis, the interrelation is especially interesting between CD54+-cells and TGF-ft in chronic process.
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| first_indexed | 2024-04-24T23:41:41Z |
| format | Article |
| id | doaj.art-d9647eda2b884815b048087bae66cc0a |
| institution | Directory Open Access Journal |
| issn | 2304-0238 2616-7352 |
| language | English |
| last_indexed | 2024-04-24T23:41:41Z |
| publishDate | 2015-01-01 |
| publisher | State Institution «Institute of Nephrology NAMS of Ukraine" |
| record_format | Article |
| series | Український Журнал Нефрології та Діалізу |
| spelling | doaj.art-d9647eda2b884815b048087bae66cc0a2024-03-15T12:23:23ZengState Institution «Institute of Nephrology NAMS of Ukraine"Український Журнал Нефрології та Діалізу2304-02382616-73522015-01-011(45)10.31450/ukrjnd.1(45).2015.0489EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITISF.Z. Gaysenyuk0SI “Institute of Nephrology NAMS of Ukraine” The aim of this work is to investigate the level of mononuclear cells, expressing intercellular adhesion molecule (CD54+), pro- (IL-1, TNF-a) and antiinflammatory (IL-4, TGF-в) blood cytokines in the patients with pyelonephritis PN, to determine the peculiarities in acute and chronic its course. Materials and methods. The immuno-enzymic method ELISA and the corresponding test-systems (“Diaclone”, “DRG”) were used to study the levels of blood cytokines and immuno-fluorescent with “Coltage” (USA) – the level of CD54+-cells. Results. It has been demonstrated that CD54+-lymphocytes, IL-1, TNF-a, IL-4 and TGF-ft in blood were increased in patients with acute and chronic pyelonephritis, compared with healthies. The number of lymphocytes expressing CD54 and the level of TGF-ft were higher in patients with chronic pyelonephritis. Conclusion. The high level of cytokines and CD54+-lymphocytes in blood ofpatients confirm their important role in immunogenesis of pyelonephritis, the interrelation is especially interesting between CD54+-cells and TGF-ft in chronic process. https://ukrjnd.com.ua/index.php/journal/article/view/89CD54 -lymphocytes, cytokines, acute and chronic pyelonephritis. |
| spellingShingle | F.Z. Gaysenyuk EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS Український Журнал Нефрології та Діалізу CD54 -lymphocytes, cytokines, acute and chronic pyelonephritis. |
| title | EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS |
| title_full | EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS |
| title_fullStr | EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS |
| title_full_unstemmed | EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS |
| title_short | EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS |
| title_sort | expression of intercellular adhesion molecule icam 1 on lymphocytes and the levels of pro and antiinflammatory cytokines in patients with pyelonephritis |
| topic | CD54 -lymphocytes, cytokines, acute and chronic pyelonephritis. |
| url | https://ukrjnd.com.ua/index.php/journal/article/view/89 |
| work_keys_str_mv | AT fzgaysenyuk expressionofintercellularadhesionmoleculeicam1onlymphocytesandthelevelsofproandantiinflammatorycytokinesinpatientswithpyelonephritis |