COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome
Coronavirus 2019 (COVID-19) has been reported to trigger Guillain–Barré syndrome (GBS). While uncommon, recurrent GBS (rGBS) episodes, triggered by antecedent viral infections, have been reported in a small proportion of GBS patients, here we describe a patient with a recurrent case of GBS, occurrin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/11/965 |
| _version_ | 1827701861445009408 |
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| author | Erin P. McDonnell Nicole J. Altomare Yesha H. Parekh Ram C. Gowda Payal D. Parikh Mark H. Lazar Martin J. Blaser |
| author_facet | Erin P. McDonnell Nicole J. Altomare Yesha H. Parekh Ram C. Gowda Payal D. Parikh Mark H. Lazar Martin J. Blaser |
| author_sort | Erin P. McDonnell |
| collection | DOAJ |
| description | Coronavirus 2019 (COVID-19) has been reported to trigger Guillain–Barré syndrome (GBS). While uncommon, recurrent GBS (rGBS) episodes, triggered by antecedent viral infections, have been reported in a small proportion of GBS patients, here we describe a patient with a recurrent case of GBS, occurring secondary to COVID-19 infection. Before this patient’s episode, he had two prior GBS flares, each precipitated by a viral infection followed by complete recovery besides intermittent paresthesias. We also consider the nosology of this illness in the spectrum of rGBS and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), with their differing natural histories, prognosis, and therapeutic approaches. For patients who have a history of inflammatory demyelinating polyradiculopathies who develop COVID-19, we recommend close observation for neurologic symptoms over the next days and weeks. |
| first_indexed | 2024-03-10T14:43:20Z |
| format | Article |
| id | doaj.art-d9652020a4ba4f85a384e457d689ba05 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T14:43:20Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-d9652020a4ba4f85a384e457d689ba052023-11-20T21:37:23ZengMDPI AGPathogens2076-08172020-11-0191196510.3390/pathogens9110965COVID-19 as a Trigger of Recurrent Guillain–Barré SyndromeErin P. McDonnell0Nicole J. Altomare1Yesha H. Parekh2Ram C. Gowda3Payal D. Parikh4Mark H. Lazar5Martin J. Blaser6Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USADepartment of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USADepartment of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USADepartment of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USADepartment of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USADepartment of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USACenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USACoronavirus 2019 (COVID-19) has been reported to trigger Guillain–Barré syndrome (GBS). While uncommon, recurrent GBS (rGBS) episodes, triggered by antecedent viral infections, have been reported in a small proportion of GBS patients, here we describe a patient with a recurrent case of GBS, occurring secondary to COVID-19 infection. Before this patient’s episode, he had two prior GBS flares, each precipitated by a viral infection followed by complete recovery besides intermittent paresthesias. We also consider the nosology of this illness in the spectrum of rGBS and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), with their differing natural histories, prognosis, and therapeutic approaches. For patients who have a history of inflammatory demyelinating polyradiculopathies who develop COVID-19, we recommend close observation for neurologic symptoms over the next days and weeks.https://www.mdpi.com/2076-0817/9/11/965SARS-CoV-2 neurological complicationsrecurrent Guillain–Barré syndromepara-infectious Guillain–Barré syndromeChronic Inflammatory Demyelinating Neuropathydemyelinating polyradiculopathies |
| spellingShingle | Erin P. McDonnell Nicole J. Altomare Yesha H. Parekh Ram C. Gowda Payal D. Parikh Mark H. Lazar Martin J. Blaser COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome Pathogens SARS-CoV-2 neurological complications recurrent Guillain–Barré syndrome para-infectious Guillain–Barré syndrome Chronic Inflammatory Demyelinating Neuropathy demyelinating polyradiculopathies |
| title | COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome |
| title_full | COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome |
| title_fullStr | COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome |
| title_full_unstemmed | COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome |
| title_short | COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome |
| title_sort | covid 19 as a trigger of recurrent guillain barre syndrome |
| topic | SARS-CoV-2 neurological complications recurrent Guillain–Barré syndrome para-infectious Guillain–Barré syndrome Chronic Inflammatory Demyelinating Neuropathy demyelinating polyradiculopathies |
| url | https://www.mdpi.com/2076-0817/9/11/965 |
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