Ex-Vivo Pharmacological Defatting of the Liver: A Review
The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/6/1253 |
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| author | Claire Goumard Célia Turco Mehdi Sakka Lynda Aoudjehane Philippe Lesnik Eric Savier Filomena Conti Olivier Scatton |
| author_facet | Claire Goumard Célia Turco Mehdi Sakka Lynda Aoudjehane Philippe Lesnik Eric Savier Filomena Conti Olivier Scatton |
| author_sort | Claire Goumard |
| collection | DOAJ |
| description | The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model. |
| first_indexed | 2024-03-10T13:08:10Z |
| format | Article |
| id | doaj.art-d966650c9292419cb7b68675ea24c377 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:08:10Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d966650c9292419cb7b68675ea24c3772023-11-21T10:57:47ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01106125310.3390/jcm10061253Ex-Vivo Pharmacological Defatting of the Liver: A ReviewClaire Goumard0Célia Turco1Mehdi Sakka2Lynda Aoudjehane3Philippe Lesnik4Eric Savier5Filomena Conti6Olivier Scatton7Department of Hepatobiliary Surgery and Liver Transplantation, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance Publique-Hopitaux de Paris, 75013 Paris, FranceDepartment of Hepatobiliary Surgery and Liver Transplantation, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance Publique-Hopitaux de Paris, 75013 Paris, FranceDepartment of Metabolic Biochemistry, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance Publique- Hopitaux de Paris, 75013 Paris, FranceSorbonne Université, Centre de Recherche Saint Antoine, INSERM UMRS-938, Institute of Cardiometabolism and Nutrition (ICAN), 75013 Paris, FranceSorbonne Université, INSERM UMRS-1166, Institute of Cardiometabolism and Nutrition (ICAN), 75013 Paris, FranceDepartment of Hepatobiliary Surgery and Liver Transplantation, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance Publique-Hopitaux de Paris, 75013 Paris, FranceSorbonne Université, Centre de Recherche Saint Antoine, INSERM UMRS-938, Institute of Cardiometabolism and Nutrition (ICAN), 75013 Paris, FranceDepartment of Hepatobiliary Surgery and Liver Transplantation, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance Publique-Hopitaux de Paris, 75013 Paris, FranceThe ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model.https://www.mdpi.com/2077-0383/10/6/1253normothermic machine perfusionex-vivo perfusionliver perfusionsteatosisdefattingliver transplantation |
| spellingShingle | Claire Goumard Célia Turco Mehdi Sakka Lynda Aoudjehane Philippe Lesnik Eric Savier Filomena Conti Olivier Scatton Ex-Vivo Pharmacological Defatting of the Liver: A Review Journal of Clinical Medicine normothermic machine perfusion ex-vivo perfusion liver perfusion steatosis defatting liver transplantation |
| title | Ex-Vivo Pharmacological Defatting of the Liver: A Review |
| title_full | Ex-Vivo Pharmacological Defatting of the Liver: A Review |
| title_fullStr | Ex-Vivo Pharmacological Defatting of the Liver: A Review |
| title_full_unstemmed | Ex-Vivo Pharmacological Defatting of the Liver: A Review |
| title_short | Ex-Vivo Pharmacological Defatting of the Liver: A Review |
| title_sort | ex vivo pharmacological defatting of the liver a review |
| topic | normothermic machine perfusion ex-vivo perfusion liver perfusion steatosis defatting liver transplantation |
| url | https://www.mdpi.com/2077-0383/10/6/1253 |
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