Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso
Background: We aimed to study the factors associated with clinical forms of lipoatrophy in patients receiving highly active antiretroviral therapy (HAART) in Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso. Methods: This cross-sectional review from March 10 to November 10, 2011, inclu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-03-01
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| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/2325957413503369 |
| _version_ | 1818537157765103616 |
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| author | Oumar Guira MD Hervé Tiéno MD Bertille Yaméogo MD Arnaud Eric Diendéré MD Nina Korsaga MD Yempabou Sagna MD Lassané Zoungrana MD Ismael Diallo MD René Traoré MD Joseph Youssouf Drabo MD |
| author_facet | Oumar Guira MD Hervé Tiéno MD Bertille Yaméogo MD Arnaud Eric Diendéré MD Nina Korsaga MD Yempabou Sagna MD Lassané Zoungrana MD Ismael Diallo MD René Traoré MD Joseph Youssouf Drabo MD |
| author_sort | Oumar Guira MD |
| collection | DOAJ |
| description | Background: We aimed to study the factors associated with clinical forms of lipoatrophy in patients receiving highly active antiretroviral therapy (HAART) in Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso. Methods: This cross-sectional review from March 10 to November 10, 2011, included a nonprobability sample of HIV-infected adults receiving antiretroviral (ARV) medications for at least 6 months and monitored in the internal medicine department. The diagnosis of lipoatrophy was clinical. Results: Three hundred patients were included. The sex ratio was 0.4 and the mean age was 42.1 ± 8.5 years. The mean duration of HAART was 73.2 ± 30.9 months. In all, 97 (32.3%) patients had lipoatrophy: 75 (25%) isolated and 22 (7.3%) mixed syndrome. Facial lipoatrophy was frequent (61.8%). Isolated lipoatrophy was associated with male sex ( P = .002) and body mass index ≤25 ( P < .05). Mixed syndrome was associated with female sex ( P = .002), age >42 years ( P < .05), physical activity ( P = .003), smoking ( P = .001), stavudine (d4T; P = .0001), or protease inhibitors ( P = .01). Conclusion: Prevention of lipoatrophy associated with HAART requires the exclusion of modifiable risk factors that we identified. |
| first_indexed | 2024-12-11T18:47:09Z |
| format | Article |
| id | doaj.art-d96937c08c3e4d079795e2c4d0a3966e |
| institution | Directory Open Access Journal |
| issn | 2325-9574 2325-9582 |
| language | English |
| last_indexed | 2024-12-11T18:47:09Z |
| publishDate | 2014-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-d96937c08c3e4d079795e2c4d0a3966e2022-12-22T00:54:25ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95742325-95822014-03-011310.1177/2325957413503369Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina FasoOumar Guira MD0Hervé Tiéno MD1Bertille Yaméogo MD2Arnaud Eric Diendéré MD3Nina Korsaga MD4Yempabou Sagna MD5Lassané Zoungrana MD6Ismael Diallo MD7René Traoré MD8Joseph Youssouf Drabo MD9Service de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de dermatologie, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoService de médecine interne, Centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou, Burkina FasoBackground: We aimed to study the factors associated with clinical forms of lipoatrophy in patients receiving highly active antiretroviral therapy (HAART) in Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso. Methods: This cross-sectional review from March 10 to November 10, 2011, included a nonprobability sample of HIV-infected adults receiving antiretroviral (ARV) medications for at least 6 months and monitored in the internal medicine department. The diagnosis of lipoatrophy was clinical. Results: Three hundred patients were included. The sex ratio was 0.4 and the mean age was 42.1 ± 8.5 years. The mean duration of HAART was 73.2 ± 30.9 months. In all, 97 (32.3%) patients had lipoatrophy: 75 (25%) isolated and 22 (7.3%) mixed syndrome. Facial lipoatrophy was frequent (61.8%). Isolated lipoatrophy was associated with male sex ( P = .002) and body mass index ≤25 ( P < .05). Mixed syndrome was associated with female sex ( P = .002), age >42 years ( P < .05), physical activity ( P = .003), smoking ( P = .001), stavudine (d4T; P = .0001), or protease inhibitors ( P = .01). Conclusion: Prevention of lipoatrophy associated with HAART requires the exclusion of modifiable risk factors that we identified.https://doi.org/10.1177/2325957413503369 |
| spellingShingle | Oumar Guira MD Hervé Tiéno MD Bertille Yaméogo MD Arnaud Eric Diendéré MD Nina Korsaga MD Yempabou Sagna MD Lassané Zoungrana MD Ismael Diallo MD René Traoré MD Joseph Youssouf Drabo MD Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso Journal of the International Association of Providers of AIDS Care |
| title | Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso |
| title_full | Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso |
| title_fullStr | Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso |
| title_full_unstemmed | Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso |
| title_short | Characteristics and Factors Associated with the Clinical Forms of Lipoatrophy during Highly Active Antiretroviral Therapy in Ouagadougou, Burkina Faso |
| title_sort | characteristics and factors associated with the clinical forms of lipoatrophy during highly active antiretroviral therapy in ouagadougou burkina faso |
| url | https://doi.org/10.1177/2325957413503369 |
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