Structure-based assessment and druggability classification of protein–protein interaction sites
Abstract The featureless interface formed by protein–protein interactions (PPIs) is notorious for being considered a difficult and poorly druggable target. However, recent advances have shown PPIs to be druggable, with the discovery of potent inhibitors and stabilizers, some of which are currently b...
Main Authors: | Lara Alzyoud, Richard A. Bryce, Mohammad Al Sorkhy, Noor Atatreh, Mohammad A. Ghattas |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-05-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-12105-8 |
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