Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer
Intestinal microorganisms are closely associated with immunity, metabolism, and inflammation, and play an important role in health and diseases such as inflammatory bowel disease, diabetes, cardiovascular disease, Parkinson’s disease, and cancer. Liver cancer is one of the most fatal cancers in huma...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.702414/full |
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| author | Chenchen Bi Geqiong Xiao Chunyan Liu Junwei Yan Jiaqi Chen Wenzhang Si Jian Zhang Zheng Liu |
| author_facet | Chenchen Bi Geqiong Xiao Chunyan Liu Junwei Yan Jiaqi Chen Wenzhang Si Jian Zhang Zheng Liu |
| author_sort | Chenchen Bi |
| collection | DOAJ |
| description | Intestinal microorganisms are closely associated with immunity, metabolism, and inflammation, and play an important role in health and diseases such as inflammatory bowel disease, diabetes, cardiovascular disease, Parkinson’s disease, and cancer. Liver cancer is one of the most fatal cancers in humans. Most of liver cancers are slowly transformed from viral hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease. However, the relationship between intestinal microbiota and their metabolites, including short-chain fatty acids, bile acids, indoles, and ethanol, and liver cancer remains unclear. Here, we summarize the molecular immune mechanism of intestinal microbiota and their metabolites in the occurrence and development of liver cancer and reveal the important role of the microbiota-gut-liver axis in liver cancer. In addition, we describe how the intestinal flora can be balanced by antibiotics, probiotics, postbiotics, and fecal bacteria transplantation to improve the treatment of liver cancer. This review describes the immunomolecular mechanism of intestinal microbiota and their metabolites in the occurrence and development of hepatic cancer and provides theoretical evidence support for future clinical practice. |
| first_indexed | 2024-12-19T07:10:17Z |
| format | Article |
| id | doaj.art-d96aa5182d4f4ddbb956817dd9845040 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T07:10:17Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d96aa5182d4f4ddbb956817dd98450402022-12-21T20:31:13ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-12-01910.3389/fcell.2021.702414702414Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver CancerChenchen Bi0Geqiong Xiao1Chunyan Liu2Junwei Yan3Jiaqi Chen4Wenzhang Si5Jian Zhang6Zheng Liu7Department of Pharmacology, Medical College of Shaoxing University, Shaoxing, ChinaDepartment of Oncology, Affiliated Hospital of Shaoxing University, Shaoxing, ChinaDepartment of Clinical Medicine, Shaoxing People’s Hospital, Shaoxing, ChinaDepartment of Pharmacology, Medical College of Shaoxing University, Shaoxing, ChinaDepartment of Pharmacology, Medical College of Shaoxing University, Shaoxing, ChinaDepartment of General Surgery, Affiliated Hospital of Shaoxing University, Shaoxing, ChinaDepartment of Pharmacology, Medical College of Shaoxing University, Shaoxing, ChinaDepartment of Pharmacology, Medical College of Shaoxing University, Shaoxing, ChinaIntestinal microorganisms are closely associated with immunity, metabolism, and inflammation, and play an important role in health and diseases such as inflammatory bowel disease, diabetes, cardiovascular disease, Parkinson’s disease, and cancer. Liver cancer is one of the most fatal cancers in humans. Most of liver cancers are slowly transformed from viral hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease. However, the relationship between intestinal microbiota and their metabolites, including short-chain fatty acids, bile acids, indoles, and ethanol, and liver cancer remains unclear. Here, we summarize the molecular immune mechanism of intestinal microbiota and their metabolites in the occurrence and development of liver cancer and reveal the important role of the microbiota-gut-liver axis in liver cancer. In addition, we describe how the intestinal flora can be balanced by antibiotics, probiotics, postbiotics, and fecal bacteria transplantation to improve the treatment of liver cancer. This review describes the immunomolecular mechanism of intestinal microbiota and their metabolites in the occurrence and development of hepatic cancer and provides theoretical evidence support for future clinical practice.https://www.frontiersin.org/articles/10.3389/fcell.2021.702414/fullintestinal florametabolitesliver canceroccurrence and developmentimmune mechanismtherapeutics |
| spellingShingle | Chenchen Bi Geqiong Xiao Chunyan Liu Junwei Yan Jiaqi Chen Wenzhang Si Jian Zhang Zheng Liu Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer Frontiers in Cell and Developmental Biology intestinal flora metabolites liver cancer occurrence and development immune mechanism therapeutics |
| title | Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer |
| title_full | Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer |
| title_fullStr | Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer |
| title_full_unstemmed | Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer |
| title_short | Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer |
| title_sort | molecular immune mechanism of intestinal microbiota and their metabolites in the occurrence and development of liver cancer |
| topic | intestinal flora metabolites liver cancer occurrence and development immune mechanism therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.702414/full |
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