Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report
Abstract Background Herpes uveitis has been previously reported to present with hyphema, but hemorrhagic hypopyon is rarely reported as a herpetic uveitis manifestation. We report a case of herpes simplex virus (HSV) presenting with hemorrhagic hypopyon, and speculate on the underlying pathophysiolo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12886-017-0591-3 |
| _version_ | 1817997521899749376 |
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| author | Andrew Winegarner Noriyasu Hashida Shizuka Koh Kohji Nishida |
| author_facet | Andrew Winegarner Noriyasu Hashida Shizuka Koh Kohji Nishida |
| author_sort | Andrew Winegarner |
| collection | DOAJ |
| description | Abstract Background Herpes uveitis has been previously reported to present with hyphema, but hemorrhagic hypopyon is rarely reported as a herpetic uveitis manifestation. We report a case of herpes simplex virus (HSV) presenting with hemorrhagic hypopyon, and speculate on the underlying pathophysiology with relation to an intravascular lymphoma which was subsequently diagnosed as a result. Case presentation We present a case wherein a 62-year-old Japanese rheumatoid arthritis woman, with HSV uveitis, presented with hemorrhagic hypopyon in the anterior chamber and a fever with photophobia. Patient was treated with antiviral drugs which improved the hyphema and corneal lesions, but lesions recurred 3 months later. This rare presentation of HSV induced uveitis, and its subsequent recurrence, aroused suspicion of an additional hypopyon-inducing pathology. On account of previous history of lung opacities and elevated LDH, intravascular lymphoma was eventually diagnosed via lung biopsy. She was treated for the lymphoma which also completely resolved all ocular symptoms without any recurrence as of 1.5 years later. Conclusion The exceedingly rare presentation of hemorrhagic hypopyon may have been enabled by an interaction of the HSV with the intravascular lymphoma. HSV involvement was indicated by the dendritic lesions, IgG assay, and response to anti-viral drugs. The ocular involvement of the intravascular lymphoma seems to be indicated by virtue of the anti-tumor drugs completely resolving all ocular symptoms. |
| first_indexed | 2024-04-14T02:38:14Z |
| format | Article |
| id | doaj.art-d96b618a8de543afb4cc79be11e4f5fb |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-14T02:38:14Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-d96b618a8de543afb4cc79be11e4f5fb2022-12-22T02:17:17ZengBMCBMC Ophthalmology1471-24152017-10-011711510.1186/s12886-017-0591-3Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case reportAndrew Winegarner0Noriyasu Hashida1Shizuka Koh2Kohji Nishida3Department of Ophthalmology, Osaka University Medical SchoolDepartment of Ophthalmology, Osaka University Medical SchoolDepartment of Ophthalmology, Osaka University Medical SchoolDepartment of Ophthalmology, Osaka University Medical SchoolAbstract Background Herpes uveitis has been previously reported to present with hyphema, but hemorrhagic hypopyon is rarely reported as a herpetic uveitis manifestation. We report a case of herpes simplex virus (HSV) presenting with hemorrhagic hypopyon, and speculate on the underlying pathophysiology with relation to an intravascular lymphoma which was subsequently diagnosed as a result. Case presentation We present a case wherein a 62-year-old Japanese rheumatoid arthritis woman, with HSV uveitis, presented with hemorrhagic hypopyon in the anterior chamber and a fever with photophobia. Patient was treated with antiviral drugs which improved the hyphema and corneal lesions, but lesions recurred 3 months later. This rare presentation of HSV induced uveitis, and its subsequent recurrence, aroused suspicion of an additional hypopyon-inducing pathology. On account of previous history of lung opacities and elevated LDH, intravascular lymphoma was eventually diagnosed via lung biopsy. She was treated for the lymphoma which also completely resolved all ocular symptoms without any recurrence as of 1.5 years later. Conclusion The exceedingly rare presentation of hemorrhagic hypopyon may have been enabled by an interaction of the HSV with the intravascular lymphoma. HSV involvement was indicated by the dendritic lesions, IgG assay, and response to anti-viral drugs. The ocular involvement of the intravascular lymphoma seems to be indicated by virtue of the anti-tumor drugs completely resolving all ocular symptoms.http://link.springer.com/article/10.1186/s12886-017-0591-3Herpes simplex uveitisIntravascular lymphomaOphthalmic manifestationsVessel permeabilityHemorrhagic hypopyonCase report |
| spellingShingle | Andrew Winegarner Noriyasu Hashida Shizuka Koh Kohji Nishida Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report BMC Ophthalmology Herpes simplex uveitis Intravascular lymphoma Ophthalmic manifestations Vessel permeability Hemorrhagic hypopyon Case report |
| title | Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report |
| title_full | Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report |
| title_fullStr | Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report |
| title_full_unstemmed | Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report |
| title_short | Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report |
| title_sort | hemorrhagic hypopyon as presenting feature of intravascular lymphoma a case report |
| topic | Herpes simplex uveitis Intravascular lymphoma Ophthalmic manifestations Vessel permeability Hemorrhagic hypopyon Case report |
| url | http://link.springer.com/article/10.1186/s12886-017-0591-3 |
| work_keys_str_mv | AT andrewwinegarner hemorrhagichypopyonaspresentingfeatureofintravascularlymphomaacasereport AT noriyasuhashida hemorrhagichypopyonaspresentingfeatureofintravascularlymphomaacasereport AT shizukakoh hemorrhagichypopyonaspresentingfeatureofintravascularlymphomaacasereport AT kohjinishida hemorrhagichypopyonaspresentingfeatureofintravascularlymphomaacasereport |